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Deciphering the immunosuppressive tumor microenvironment in ALK- and EGFR-positive lung adenocarcinoma

The advent of immune checkpoint blockade (ICB) has led to significantly improved disease outcome in lung adenocarcinoma (ADC), but response of ALK/EGFR-positive tumors to immune therapy is limited. The underlying immune biology is incompletely understood.

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Bibliographic Details
Main Authors: Budczies, Jan (Author) , Kirchner, Martina (Author) , Kluck, Klaus (Author) , Kazdal, Daniel (Author) , Glade, Julia (Author) , Allgäuer, Michael (Author) , Kriegsmann, Mark (Author) , Heußel, Claus Peter (Author) , Herth, Felix (Author) , Winter, Hauke (Author) , Meister, Michael (Author) , Muley, Thomas (Author) , Goldmann, Torsten (Author) , Fröhling, Stefan (Author) , Wermke, Martin (Author) , Waller, Cornelius (Author) , Tufman, Amanda L. H. (Author) , Reck, Martin (Author) , Peters, Solange (Author) , Schirmacher, Peter (Author) , Thomas, Michael (Author) , Christopoulos, Petros (Author) , Stenzinger, Albrecht (Author)
Format: Article (Journal)
Language:English
Published: 14 June 2021
In: Cancer immunology immunotherapy
Year: 2021, Volume: 71, Issue: 2, Pages: 251-265
ISSN:1432-0851
DOI:10.1007/s00262-021-02981-w
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00262-021-02981-w
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Author Notes:Jan Budczies, Martina Kirchner, Klaus Kluck, Daniel Kazdal, Julia Glade, Michael Allgäuer, Mark Kriegsmann, Claus-Peter Heußel, Felix J. Herth, Hauke Winter, Michael Meister, Thomas Muley, Torsten Goldmann, Stefan Fröhling, Martin Wermke, Cornelius F. Waller, Amanda Tufman, Martin Reck, Solange Peters, Peter Schirmacher, Michael Thomas, Petros Christopoulos, Albrecht Stenzinger
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Summary:The advent of immune checkpoint blockade (ICB) has led to significantly improved disease outcome in lung adenocarcinoma (ADC), but response of ALK/EGFR-positive tumors to immune therapy is limited. The underlying immune biology is incompletely understood.
Item Description:Gesehen am 05.05.2023
Physical Description:Online Resource
ISSN:1432-0851
DOI:10.1007/s00262-021-02981-w

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