Deciphering the immunosuppressive tumor microenvironment in ALK- and EGFR-positive lung adenocarcinoma
The advent of immune checkpoint blockade (ICB) has led to significantly improved disease outcome in lung adenocarcinoma (ADC), but response of ALK/EGFR-positive tumors to immune therapy is limited. The underlying immune biology is incompletely understood.
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
14 June 2021
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| In: |
Cancer immunology immunotherapy
Year: 2021, Volume: 71, Issue: 2, Pages: 251-265 |
| ISSN: | 1432-0851 |
| DOI: | 10.1007/s00262-021-02981-w |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00262-021-02981-w
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| Author Notes: | Jan Budczies, Martina Kirchner, Klaus Kluck, Daniel Kazdal, Julia Glade, Michael Allgäuer, Mark Kriegsmann, Claus-Peter Heußel, Felix J. Herth, Hauke Winter, Michael Meister, Thomas Muley, Torsten Goldmann, Stefan Fröhling, Martin Wermke, Cornelius F. Waller, Amanda Tufman, Martin Reck, Solange Peters, Peter Schirmacher, Michael Thomas, Petros Christopoulos, Albrecht Stenzinger |
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| 520 | |a The advent of immune checkpoint blockade (ICB) has led to significantly improved disease outcome in lung adenocarcinoma (ADC), but response of ALK/EGFR-positive tumors to immune therapy is limited. The underlying immune biology is incompletely understood. | ||
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| 650 | 4 | |a EGFR mutation | |
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| 650 | 4 | |a Lung adenocarcinoma | |
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