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Impact of systolic and diastolic deformation indexes assessed by strain-encoded imaging to predict persistent severe myocardial dysfunction in patients after acute myocardial infarction at follow-up

Objectives - This study evaluated the value of systolic and diastolic deformation indexes determined by strain-encoded imaging to predict persistent severe dysfunction at follow-up in patients after reperfused acute myocardial infarction (AMI) in comparison with late gadolinium enhancement (LGE). -...

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Hauptverfasser: Neizel-Wittke, Mirja (VerfasserIn) , Korosoglou, Grigorios (VerfasserIn) , Loßnitzer, Dirk (VerfasserIn) , Kühl, Harald (VerfasserIn) , Hoffmann, Rainer (VerfasserIn) , Ocklenburg, Christina (VerfasserIn) , Giannitsis, Evangelos (VerfasserIn) , Osman, Nael F. (VerfasserIn) , Katus, Hugo (VerfasserIn) , Steen, Henning (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 16 September 2010
In: Journal of the American College of Cardiology
Year: 2010, Jahrgang: 56, Heft: 13, Pages: 1056-1062
ISSN:1558-3597
DOI:10.1016/j.jacc.2010.02.070
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jacc.2010.02.070
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S073510971002574X
Volltext
Verfasserangaben:Mirja Neizel, MD, Grigorios Korosoglou, MD, Dirk Lossnitzer, MD, Harald Kühl, MD, Rainer Hoffmann, MD, Christina Ocklenburg, MSC, Evangelos Giannitsis, MD, Nael F. Osman, PHD, Hugo A. Katus, MD, Henning Steen, MD
Beschreibung
Zusammenfassung:Objectives - This study evaluated the value of systolic and diastolic deformation indexes determined by strain-encoded imaging to predict persistent severe dysfunction at follow-up in patients after reperfused acute myocardial infarction (AMI) in comparison with late gadolinium enhancement (LGE). - Background - Animal studies suggest that regional diastolic function provides information about myocardial viability after AMI. However, data in humans are sparse. - Methods - Twenty-six patients underwent magnetic resonance imaging 3 ± 1 days after successfully reperfused ST-segment elevation myocardial infarction and at a follow-up of 6 months. Cine, strain-encoded, and LGE images were acquired. Peak systolic circumferential strain (Ecc) and early diastolic strain rate (Ecc/s) were calculated for each segment at baseline and at follow-up. A cutoff Ecc value of −9% was used to define severe dysfunction at follow-up. - Results - A total of 312 segments were analyzed; 119 segments showed abnormal baseline function. Thirty-five segments showed severe dysfunction at follow-up, which was defined as Ecc at follow-up <9%. The area under the curve for Ecc/s was 0.82 (95% confidence interval [CI]: 0.72 to 0.89), for Ecc 0.74 (95% CI: 0.64 to 0.83), and for LGE 0.85 (95% CI: 0.77 to 0.92). A comparison of receiver-operating characteristic curves demonstrates that LGE is not significantly different than Ecc/s but is significantly different than Ecc (p = 0.32 vs. p < 0.05) for prediction of severe dysfunction at follow-up. - Conclusions - Regional diastolic function provides similar accuracy to predict persistent severe dysfunction at follow-up to LGE and is superior to regional systolic function in patients after AMI. Diastolic deformation indexes may serve as a new parameter for assessment of viability in patients after AMI. (SENC in AMI Study; NCT00752713).
Beschreibung:Gesehen am 08.05.2023
Beschreibung:Online Resource
ISSN:1558-3597
DOI:10.1016/j.jacc.2010.02.070

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