Body mass index interacts with sex to predict readmission in in-patients with alcohol use disorder
A previous highly controlled pilot study revealed that body mass index (BMI) predicts outcome of in-patients with alcohol use disorder (AUD) in a sex-specific manner. We here provide translational evidence from a daily clinical routine setting and investigated whether BMI and sex interact to predict...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 2023
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| In: |
Addiction biology
Year: 2023, Jahrgang: 28, Heft: 1, Pages: 1-8 |
| ISSN: | 1369-1600 |
| DOI: | 10.1111/adb.13239 |
| Online-Zugang: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1111/adb.13239 Verlag, kostenfrei, Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/adb.13239 
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| Verfasserangaben: | Sabine Hoffmann, Sarah Gerhardt, Anne Koopmann, Patrick Bach, Wolfgang H. Sommer, Falk Kiefer, Massimiliano Mazza, Bernd Lenz |
| Zusammenfassung: | A previous highly controlled pilot study revealed that body mass index (BMI) predicts outcome of in-patients with alcohol use disorder (AUD) in a sex-specific manner. We here provide translational evidence from a daily clinical routine setting and investigated whether BMI and sex interact to predict 24-month readmission risk in four naturalistic cohorts of a specialized addiction clinic (i.e., all patients admitted to the clinic from 2016 to 2020): (i) in-patients (443 males and 197 females) and (ii) day clinic patients (241 males and 103 females) with a primary diagnosis of AUD; (iii) in-patients (175 males and 98 females) and (iv) day clinic patients (174 males and 64 females) with a primary substance use disorder (SUD) other than alcohol. In the in-patients with AUD, BMI interacted with sex to predict the 24-month readmission risks (p = 0.008; after adjustment for age and liver enzyme activities: p = 0.012); with higher BMI, the risk increases significantly in males, whereas for females, the risk tends to decrease. In the group of overweight in-patients, we found higher readmission rates in males relative to females with an odds ratio of 1.8 (p = 0.038). No such significant effects were found in the other cohorts. This study's findings support previous results, suggesting that the easily accessible BMI may serve as a predictive and sex-sensitive biomarker for outcome in in-patients with AUD. Future studies are necessary to elucidate the underlying aetiopathological mechanisms. |
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| Beschreibung: | First published: 02 November 2022 Gesehen am 08.05.2023 |
| Beschreibung: | Online Resource |
| ISSN: | 1369-1600 |
| DOI: | 10.1111/adb.13239 |