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Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9

Infection with the high-risk HPV types 16 and 18 is the major cause of cervical cancer and plays a role in the development of certain head and neck and skin cancers. We have previously demonstrated that the Early Protein 2 of the Cottontail Rabbit papillomavirus (CRPV), required for skin carcinogene...

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Bibliographic Details
Main Authors: Mühlen, Sabrina (Author) , Behren, Andreas (Author) , Iftner, Thomas (Author) , Simon, Christian (Author)
Format: Article (Journal)
Language:English
Published: August 1, 2010
In: International journal of oncology
Year: 2010, Volume: 37, Issue: 2, Pages: 337-345
ISSN:1791-2423
DOI:10.3892/ijo_00000682
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3892/ijo_00000682
Verlag, lizenzpflichtig, Volltext: https://www.spandidos-publications.com/10.3892/ijo_00000682
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Author Notes:Sabrina Mühlen, Andreas Behren, Thomas Iftner and Christian Simon
Description
Summary:Infection with the high-risk HPV types 16 and 18 is the major cause of cervical cancer and plays a role in the development of certain head and neck and skin cancers. We have previously demonstrated that the Early Protein 2 of the Cottontail Rabbit papillomavirus (CRPV), required for skin carcinogenesis in a rabbit model, is able to induce the expression of a matrix metalloproteinase (MMP-9); a protease known to play a key role in invasion and metastasis. However, as of now we do not understand the underlying mechanism of activation nor relevance for the human system. Here, we report that high-risk human papillomavirus HPV16 E2 similar to our previously reported results on CRPV E2 activates the human MMP-9 promoter predominantly via the MEK1-ERK1/2-AP-1-signaling pathway. In addition this activation is associated with a nuclear sub-localisation of HPV16-E2 suggesting a nuclear protein-protein or protein-DNA interaction of E2 as the underlying mechanism of activation.
Item Description:Gesehen am 10.05.2023
Physical Description:Online Resource
ISSN:1791-2423
DOI:10.3892/ijo_00000682

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