CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation$nletters

Recent studies have shown that neutrophil extracellular traps (NETs) can capture and kill bacteria but may also contribute to chronic inflammation. The mechanisms that trigger NET formation are not yet fully elucidated. Marcos et al. now report that stimulation of the chemokine receptor CXCR, induce...

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Main Authors: Marcos-Nickol, Veronica (Author) , Zhou-Suckow, Zhe (Author) , Yildirim, Ali Önder (Author) , Bohla, Alexander (Author) , Hector, Andreas (Author) , Vitkov, Ljubomir (Author) , Wiedenbauer, Eva-Maria (Author) , Krautgartner, Wolf Dietrich (Author) , Stoiber, Walter (Author) , Belohradsky, Bernd H. (Author) , Rieber, Nikolaus (Author) , Kormann, Michael (Author) , Koller, Barbara (Author) , Roscher, Adelbert (Author) , Roos, Dirk (Author) , Griese, Matthias (Author) , Eickelberg, Oliver (Author) , Döring, Gerd (Author) , Mall, Marcus A. (Author) , Hartl, Dominik (Author)
Format: Article (Journal)
Language:English
Published: 05 September 2010
In: Nature medicine
Year: 2010, Volume: 16, Issue: 9, Pages: 1018-1023
ISSN:1546-170X
DOI:10.1038/nm.2209
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nm.2209
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nm.2209
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Author Notes:Veronica Marcos, Zhe Zhou, Ali Önder Yildirim, Alexander Bohla, Andreas Hector, Ljubomir Vitkov, Eva-Maria Wiedenbauer, Wolf Dietrich Krautgartner, Walter Stoiber, Bernd H Belohradsky, Nikolaus Rieber, Michael Kormann, Barbara Koller, Adelbert Roscher, Dirk Roos, Matthias Griese, Oliver Eickelberg, Gerd Döring, Marcus A Mall & Dominik Hartl
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Summary:Recent studies have shown that neutrophil extracellular traps (NETs) can capture and kill bacteria but may also contribute to chronic inflammation. The mechanisms that trigger NET formation are not yet fully elucidated. Marcos et al. now report that stimulation of the chemokine receptor CXCR, induces NET formation and that NETs are present in airway fluids of individuals with cystic fibrosis. Blocking CXCR2 activation in the lung reduced NET formation and improved lung function in a mouse model of cystic fibrosis.
Item Description:Der Artikel wurde am 7. Juli 2011 zurückgezogen
Gesehen am 10.05.2023
Physical Description:Online Resource
ISSN:1546-170X
DOI:10.1038/nm.2209