Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer

The discovery of ERG/ETV 1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa). The study objective was to evaluate the potential clinical significance and natural history of different disease categories by combining E...

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Main Authors: Reid, Alison (Author) , Attard, G. (Author) , Ambroisine, L. (Author) , Fisher, G. (Author) , Kovacs, Gyula (Author) , Brewer, D. (Author) , Clark, J. (Author) , Flohr, P. (Author) , Edwards, S. (Author) , Berney, D. M. (Author) , Foster, C. S. (Author) , Fletcher, A. (Author) , Gerald, W. L. (Author) , Møller, H. (Author) , Reuter, V. E. (Author) , Scardino, P. T. (Author) , Cuzick, J. (Author) , de Bono, J. S. (Author) , Cooper, C. S. (Author)
Format: Article (Journal)
Language:English
Published: 26 January 2010
In: British journal of cancer
Year: 2010, Volume: 102, Issue: 4, Pages: 678-684
ISSN:1532-1827
DOI:10.1038/sj.bjc.6605554
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/sj.bjc.6605554
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/6605554
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Author Notes:AHM Reid, G Attard, L Ambroisine, G Fisher, G Kovacs, D Brewer, J Clark, P Flohr, S Edwards, DM Berney, CS Foster, A Fletcher, WL Gerald, H Møller, VE Reuter, PT Scardino, J Cuzick, JS de Bono, and CS Cooper on behalf of the Transatlantic Prostate Group
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Summary:The discovery of ERG/ETV 1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa). The study objective was to evaluate the potential clinical significance and natural history of different disease categories by combining ERG/ETV 1 gene rearrangements and PTEN gene loss status.
Item Description:Gesehen am 12.05.2023
Physical Description:Online Resource
ISSN:1532-1827
DOI:10.1038/sj.bjc.6605554