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A super-agonist of growth hormone-releasing hormone causes rapid improvement of nutritional status in patients with chronic kidney disease

Chronic kidney disease is frequently associated with protein-energy wasting related to chronic inflammation and a resistance to anabolic hormones such as insulin and growth hormone (GH). In this study, we determined whether a new GH-releasing hormone super-agonist (AKL-0707) improved the anabolism a...

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Main Authors: Niemczyk, Stanisław (Author) , Sikorska, Hanna (Author) , Więcek, Andrzej (Author) , Żukowska-Szczechowska, Ewa (Author) , Załęcka, Klaudia (Author) , Gorczyńska, Joanna (Author) , Kubik, Małgorzata (Author) , Czerwieńska, Beata (Author) , Gosek, Katarzyna (Author) , Veldhuis, Johannes D. (Author) , Wagner, David A. (Author) , Gaudreau, Pierrette (Author) , Hakonen, Tiina (Author) , Kay, Sam Wai Kit (Author) , Jouhikainen, Taneli (Author) , Schaefer, Franz (Author)
Format: Article (Journal)
Language:English
Published: 2010
In: Kidney international
Year: 2010, Volume: 77, Issue: 5, Pages: 450-458
ISSN:1523-1755
DOI:10.1038/ki.2009.480
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ki.2009.480
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0085253815542713
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Author Notes:Stanisław Niemczyk, Hanna Sikorska, Andrzej Więcek, Ewa Żukowska-Szczechowska, Klaudia Załęcka, Joanna Gorczyńska, Małgorzata Kubik, Beata Czerwieńska, Katarzyna Gosek, Johannes D. Veldhuis, David A. Wagner, Pierrette Gaudreau, Tiina Hakonen, Sam Wai Kit Kay, Taneli Jouhikainen and Franz Schaefer
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Summary:Chronic kidney disease is frequently associated with protein-energy wasting related to chronic inflammation and a resistance to anabolic hormones such as insulin and growth hormone (GH). In this study, we determined whether a new GH-releasing hormone super-agonist (AKL-0707) improved the anabolism and nutritional status of nondialyzed patients with stage 4-5 chronic kidney disease randomized to twice daily injections of the super-agonist or placebo. After 28 days, this treatment significantly increased 24-h GH secretion by almost 400%, without altering the frequency or rhythmicity of secretory bursts or fractional pulsatile GH release, and doubled the serum insulin-like growth factor-1 level. There was a significant change in the Subjective Global Assessment from ‘mildly to moderately malnourished’ to ‘well-nourished’ in 6 of 9 patients receiving AKL-0707 but in none of 10 placebo-treated patients. By dual-energy X-ray absorptiometry, both the mean fat-free mass and the body mineral content increased, but fat mass decreased, all significantly. In the AKL-0707-treated group, both serum urea and normalized protein equivalent of nitrogen appearance significantly decreased with no change in dietary protein intake, indicating a protein anabolic effect of treatment. Thus, our study shows that stimulation of endogenous GH secretion by AKL-0707 overcomes uremic catabolism of patients with advanced chronic kidney disease.
Item Description:Online veröffentlicht 16 December 200
Gesehen am 15.05.2023
Physical Description:Online Resource
ISSN:1523-1755
DOI:10.1038/ki.2009.480

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