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Response and remission criteria in major depression - a validation of current practice

Remission and response were suggested as the most relevant outcome criteria for the treatment of depression. There is still marked uncertainty as to what cut-offs should be used on current depression rating scales. The goal of the present study was to compare the validity of different HAMD, MADRS an...

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Main Authors: Riedel, Michael (Author) , Möller, Hans-Jürgen (Author) , Obermeier, Michael (Author) , Schennach-Wolff, Rebecca (Author) , Bauer, Michael (Author) , Adli, Mazda (Author) , Kronmüller, Klaus-Thomas (Author) , Nickel, Thomas (Author) , Brieger, Peter (Author) , Laux, Gerd (Author) , Bender, Wolfram (Author) , Heuser, Isabella (Author) , Zeiler, Joachim (Author) , Gaebel, Wolfgang (Author) , Seemüller, Florian (Author)
Format: Article (Journal)
Language:English
Published: 5 May 2010
In: Journal of psychiatric research
Year: 2010, Volume: 44, Issue: 15, Pages: 1063-1068
ISSN:1879-1379
DOI:10.1016/j.jpsychires.2010.03.006
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jpsychires.2010.03.006
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0022395610000750
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Author Notes:Michael Riedel, Hans-Jürgen Möller, Michael Obermeier, Rebecca Schennach-Wolff, Michael Bauer, Mazda Adli, Klaus Kronmüller, Thomas Nickel, Peter Brieger, Gerd Laux, Wolfram Bender, Isabella Heuser, Joachim Zeiler, Wolfgang Gaebel, Florian Seemüller
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Summary:Remission and response were suggested as the most relevant outcome criteria for the treatment of depression. There is still marked uncertainty as to what cut-offs should be used on current depression rating scales. The goal of the present study was to compare the validity of different HAMD, MADRS and BDI cut-offs for response and remission. The naturalistic prospective study was performed in 12 psychiatric hospitals in Germany. All evaluable patients (n=846) were hospitalized and had to meet DSM-IV criteria for major depressive disorder. Biweekly ratings were assessed using HAMD-21, MADRS and BDI. A CGI-S score of 1 and a CGI-I score of at least 2 was used as the primary comparative measure of remission and response, respectively. A HAMD-21 cut-off≤7 (AUC: 0.92), HAMD-17 cut-of≤6 (AUC: 0.90), MADRS cut-off≤7 (AUC: 0.94) and BDI cut-off≤12 (AUC: 0.83) were associated with a maximum of specificity and sensitivity for defining remission. A minimum decrease of 47% of the HAMD-21 (AUC: 0.90), ≤57% for HAMD-17 (AUC: 0.89), ≤ 46% for MADRS (0.91) and a decrease of 47% for the BDI baseline score (AUC: 0.78) best corresponded CGI response criteria. Our data largely confirmed currently used remission and response criteria in naturalistically treated patients.
Item Description:Gesehen am 15.05.2023
Physical Description:Online Resource
ISSN:1879-1379
DOI:10.1016/j.jpsychires.2010.03.006

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