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Hematopoietic stem cell boost for persistent neutropenia after CAR T-cell therapy: a GLA/DRST study

Hematotoxicity after chimeric antigen receptor (CAR) T-cell therapy is associated with infection and death but management remains unclear. We report results of 31 patients receiving hematopoietic stem cell boost (HSCB; 30 autologous, 1 allogeneic) for either sustained severe neutropenia of grade 4 (...

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Main Authors: Gagelmann, Nico (Author) , Wulf, Gerald Georg (Author) , Duell, Johannes (Author) , Glaß, Bertram (Author) , Heteren, Pearl van (Author) , Tresckow, Bastian von (Author) , Fischer, Monika (Author) , Penack, Olaf (Author) , Ayuk, Francis (Author) , Einsele, Herrmann (Author) , Holtick, Udo (Author) , Thomson, Julia (Author) , Dreger, Peter (Author) , Kröger, Nicolaus (Author)
Format: Article (Journal)
Language:English
Published: 20 February 2023
In: Blood advances
Year: 2023, Volume: 7, Issue: 4, Pages: 555-559
ISSN:2473-9537
DOI:10.1182/bloodadvances.2022008042
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/bloodadvances.2022008042
Verlag, lizenzpflichtig, Volltext: https://ashpublications.org/bloodadvances/article/7/4/555/485535/Hematopoietic-stem-cell-boost-for-persistent
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Author Notes:Nico Gagelmann, Gerald Georg Wulf, Johannes Duell, Bertram Glass, Pearl van Heteren, Bastian von Tresckow, Monika Fischer, Olaf Penack, Francis Ayuk, Herrmann Einsele, Udo Holtick, Julia Thomson, Peter Dreger, and Nicolaus Kröger
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Summary:Hematotoxicity after chimeric antigen receptor (CAR) T-cell therapy is associated with infection and death but management remains unclear. We report results of 31 patients receiving hematopoietic stem cell boost (HSCB; 30 autologous, 1 allogeneic) for either sustained severe neutropenia of grade 4 (<0.5 × 109/L), sustained moderate neutropenia (≤1.5 × 109/L) and high risk of infection, or neutrophil count ≤2.0 × 109/L and active infection. ...
Item Description:Online-Vorabveröffentlichung: 13. Juni 2022
Gesehen am 16.11.2023
Physical Description:Online Resource
ISSN:2473-9537
DOI:10.1182/bloodadvances.2022008042

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