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Co-expression and clinical utility of AR-FL and AR splice variants AR-V3, AR-V7 and AR-V9 in prostate cancer

Androgen receptor (AR) splice variants (AR-Vs) have been discussed as a biomarker in prostate cancer (PC). However, some reports question the predictive property of AR-Vs. From a mechanistic perspective, the connection between AR full length (AR-FL) and AR-Vs is not fully understood. Here, we aimed...

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Main Authors: Wüstmann, Neele (Author) , Seitzer, Konstantin (Author) , Humberg, Verena (Author) , Vieler, Julia (Author) , Grundmann, Norbert (Author) , Steinestel, Julie (Author) , Tiedje, Dorothee (Author) , Duensing, Stefan (Author) , Krabbe, Laura-Maria (Author) , Bögemann, Martin (Author) , Schrader, Andres Jan (Author) , Bernemann, Christof (Author) , Schlack, Katrin (Author)
Format: Article (Journal)
Language:English
Published: 05 April 2023
In: Biomarker Research
Year: 2023, Volume: 11, Pages: 1-14
ISSN:2050-7771
DOI:10.1186/s40364-023-00481-w
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s40364-023-00481-w
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Author Notes:Neele Wüstmann, Konstantin Seitzer, Verena Humberg, Julia Vieler, Norbert Grundmann, Julie Steinestel, Dorothee Tiedje, Stefan Duensing, Laura-Maria Krabbe, Martin Bögemann, Andres Jan Schrader, Christof Bernemann and Katrin Schlack
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Summary:Androgen receptor (AR) splice variants (AR-Vs) have been discussed as a biomarker in prostate cancer (PC). However, some reports question the predictive property of AR-Vs. From a mechanistic perspective, the connection between AR full length (AR-FL) and AR-Vs is not fully understood. Here, we aimed to investigate the dependence of AR-FL and AR-V expression levels on AR gene activity. Additionally, we intended to comprehensively analyze presence of AR-FL and three clinically relevant AR-Vs (AR-V3, AR-V7 and AR-V9) in different stages of disease, especially with respect to clinical utility in PC patients undergoing AR targeted agent (ARTA) treatment.
Item Description:Gesehen am 17.05.2023
Physical Description:Online Resource
ISSN:2050-7771
DOI:10.1186/s40364-023-00481-w

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