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Histone deacetylase (HDAC) 1 and 2 expression and chemotherapy in gastric cancer

Histone deacetylases (HDACs) modulate chromatin and may influence the effect of DNA-damaging drugs. We investigated HDAC1 and -2 expression in gastric carcinomas (GCs) for an association of patient outcome with conventional neoadjuvant chemotherapy. In vitro, HDAC inhibitors were evaluated as altern...

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Main Authors: Mutze, Kathrin Isabelle Amelie (Author) , Langer, Rupert (Author) , Becker, Karen (Author) , Ott, Katja (Author) , Novotny, Alexander (Author) , Luber, Birgit (Author) , Hapfelmeier, Alexander (Author) , Göttlicher, Martin (Author) , Höfler, Heinz (Author) , Keller, Gisela (Author)
Format: Article (Journal)
Language:English
Published: 29 June 2010
In: Annals of surgical oncology
Year: 2010, Volume: 17, Issue: 12, Pages: 3336-3343
ISSN:1534-4681
DOI:10.1245/s10434-010-1182-1
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1245/s10434-010-1182-1
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Author Notes:Kathrin Mutze, Rupert Langer, MD, Karen Becker, MD, Katja Ott, MD, Alexander Novotny, MD, Birgit Luber, PhD, Alexander Hapfelmeier, Martin Göttlicher, MD, Heinz Höfler, MD, and Gisela Keller, PhD
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Summary:Histone deacetylases (HDACs) modulate chromatin and may influence the effect of DNA-damaging drugs. We investigated HDAC1 and -2 expression in gastric carcinomas (GCs) for an association of patient outcome with conventional neoadjuvant chemotherapy. In vitro, HDAC inhibitors were evaluated as alternative treatment options.
Item Description:Gesehen am 17.05.2023
Physical Description:Online Resource
ISSN:1534-4681
DOI:10.1245/s10434-010-1182-1

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