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Analysis of bisphenol-propane in dialyzer and its effect on human body

The effect of trace solvent bisphenol A (BPA) in polyether sulfone hollow fiber membrane Enttex™-16LF (E60) (produced by 3 M) low-throughput dialyzer was tested in this study. Animal experiments were conducted to evaluate its genotoxicity, carcinogenicity, and teratogenicity upon - chronic exposure....

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Main Authors: Yun, Chen (Author) , He, Xiaofan (Author) , Xie, Ting (Author) , Chi-Wa, Ao-Ieong (Author) , Li, Weilong (Author) , Song, Zhuoheng (Author) , Xiao, Mengyun (Author) , Meng, Yu (Author) , Hu, Bo (Author) , Guan, Baozhang (Author) , Yang, Lifeng (Author) , Ye, Mingjun (Author) , Zeng, Huiyi (Author) , Morgera, Stanislao (Author) , Krämer, Bernhard (Author) , Weiler, Wolfgang (Author) , Yin, Lianghong (Author) , Luan, Shaodong (Author) , Xu, Suhua (Author) , Hocher, Berthold (Author)
Format: Article (Journal)
Language:English
Published: 1. Januar 2023
In: Materials express
Year: 2023, Volume: 13, Issue: 1, Pages: 170-181
ISSN:2158-5857
DOI:10.1166/mex.2023.2327
Online Access:Verlag, lizenzpflichtig, Volltext: https://dx.doi.org/10.1166/mex.2023.2327
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Author Notes:Chen Yun, Xiaofan He, Ting Xie, Ao-Ieong Chi-Wa, Weilong Li, Zhuoheng Song, Mengyun Xiao, Yu Meng, Bo Hu, Baozhang Guan, Lifeng Yang, Mingjun Ye, Huiyi Zeng, Stanislao Morgera, Bernhard Krämer, Wolfganng, Lianghong Yin, Shaodong Luan, Suhua Xu, and Berthold Hocher
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Summary:The effect of trace solvent bisphenol A (BPA) in polyether sulfone hollow fiber membrane Enttex™-16LF (E60) (produced by 3 M) low-throughput dialyzer was tested in this study. Animal experiments were conducted to evaluate its genotoxicity, carcinogenicity, and teratogenicity upon - chronic exposure. The dialyzer was operated at 200 mL/min and 400 mL/min and coupled with LC-20AT liquid chromatography to detect BPA, which showed that the BPA content was less than 5 μg/kg/d at both flow rates. In animal experiments, the tolerable intake (T.I.) was calculated to - be 0.5 μg/kg/d. With hemodialysis three times per week, the average patient weight was calculated at 70 kg, and the average daily BPA exposure was 0.0306 μg/kg/d. The risk of residual BPA was within the acceptable limit with polyether sulfone membrane Enttex™-16LF - (E60) hollow fiber dialyzer from 3 M, without inducing risk for disability, teratogenicity, or genotoxicity.
Item Description:Gesehen am 22.05.2023
Physical Description:Online Resource
ISSN:2158-5857
DOI:10.1166/mex.2023.2327

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