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Corpus callosum tissue loss and development of motor and global cognitive impairment: the LADIS study

Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging...

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Hauptverfasser: Frederiksen, Kristian Steen (VerfasserIn) , Garde, Ellen (VerfasserIn) , Skimminge, Arnold (VerfasserIn) , Barkhof, Frederik (VerfasserIn) , Scheltens, Philip (VerfasserIn) , Straaten, Elisabeth C. W. van (VerfasserIn) , Fazekas, Franz (VerfasserIn) , Bäzner, Hansjörg (VerfasserIn) , Verdelho, Ana (VerfasserIn) , Ferro, José M. (VerfasserIn) , Erkinjuntti, Timo (VerfasserIn) , Jokinen, Hanna (VerfasserIn) , Wahlund, Lars-Olof (VerfasserIn) , O’Brien, John T. (VerfasserIn) , Basile, Anna M. (VerfasserIn) , Pantoni, Leonardo (VerfasserIn) , Inzitari, Domenico (VerfasserIn) , Waldemar, Gunhild (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: January 19, 2012
In: Dementia and geriatric cognitive disorders
Year: 2012, Jahrgang: 32, Heft: 4, Pages: 279-286
ISSN:1421-9824
DOI:10.1159/000334949
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000334949
Volltext
Verfasserangaben:Kristian S. Frederiksen, Ellen Garde, Arnold Skimminge, Frederik Barkhof, Philip Scheltens, Elisabeth C.W. van Straaten, Franz Fazekas, Hansjörg Baezner, Ana Verdelho, José M. Ferro, Timo Erkinjuntti, Hanna Jokinen, Lars-Olof Wahlund, John T. O’Brien, Anna M. Basile, Leonardo Pantoni, Domenico Inzitari, Gunhild Waldemar on behalf of the LADIS study group
Beschreibung
Zusammenfassung:Objective: To examine the impact of corpus callosum (CC) tissue loss on the development of global cognitive and motor impairment in the elderly. Methods: This study was based on the Leukoaraiosis and Disability (LADIS) study. Assessment of cognitive and motor functions and magnetic resonance imaging (MRI) were done at baseline and at a 3-year follow-up in nondemented elderly subjects. Results: 328 of 639 LADIS subjects had MRIs at baseline and at the 3-year follow-up, which allowed for assessment of CC. Logistic regression revealed differential tissue loss rates in posterior CC in subjects converting to dementia, compared to nonconverters (p < 0.05). Anterior and posterior CC tissue loss was significantly correlated with self-perceived memory impairment in nonconverters (p < 0.05). CC tissue loss was also significantly associated with impaired single leg stance time (p < 0.01). Conclusion: The present longitudinal study on CC supports the role of callosal tissue loss in the development of global cognitive as well as motor impairment.
Beschreibung:Gesehen am 22.05.2023
Erscheinungsjahr im PDF in der Kopf- und Fußzeile: Dement Geriatr Cogn Disord 2011;32:279–286, Urheberrecht: 2012 S. Karger AG, Basel ; Erscheinungsjahr auf der Frontdoor: Dement Geriatr Cogn Disord (2012) 32 (4): 279–286, online veröffentlicht:Januar 19 2012
Beschreibung:Online Resource
ISSN:1421-9824
DOI:10.1159/000334949

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