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Prevalence and determinants of reticular pseudodrusen in the Russian Ural Eye and Medical Study

Purpose To assess the prevalence of reticular pseudodrusen (RPD) and their determinants. Methods The Population-based Ural Eye and Medical Study conducted in Bashkortostan/Russia included 5899 participants aged 40+ years. Presence of RPDs was assessed on conventional colour fundus photographs, red-f...

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Main Authors: Bikbov, Mukharram (Author) , Kazakbaeva, Gyulli M. (Author) , Rakhimova, Ellina M. (Author) , Rusakova, Iuliia A. (Author) , Gilmanshin, Timur R. (Author) , Zainullin, Rinat M. (Author) , Panda-Jonas, Songhomitra (Author) , Fakhretdinova, Albina A. (Author) , Tuliakova, Azaliia M. (Author) , Safiullina, Kamilia R. (Author) , Bolshakova, Natalia I. (Author) , Gizzatov, Ainur V. (Author) , Ponomarev, Ildar P. (Author) , Jonas, Jost B. (Author)
Format: Article (Journal)
Language:English
Published: December 2022
In: Acta ophthalmologica
Year: 2022, Volume: 100, Issue: 8, Pages: e1701-e1707
ISSN:1755-3768
DOI:10.1111/aos.15145
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/aos.15145
Verlag, kostenfrei, Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/aos.15145
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Author Notes:Mukharram M. Bikbov, Gyulli M. Kazakbaeva, Ellina M. Rakhimova, Iuliia A. Rusakova, Timur R. Gilmanshin, Rinat M. Zainullin, Songhomitra Panda-Jonas, Albina A. Fakhretdinova, Azaliia M. Tuliakova, Kamilia R. Safiullina, Natalia I. Bolshakova, Ainur V. Gizzatov, Ildar P. Ponomarev and Jost B. Jonas
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Summary:Purpose To assess the prevalence of reticular pseudodrusen (RPD) and their determinants. Methods The Population-based Ural Eye and Medical Study conducted in Bashkortostan/Russia included 5899 participants aged 40+ years. Presence of RPDs was assessed on conventional colour fundus photographs, red-free fundus images and optical coherence tomographic images. Results The study included 4914 (83.3%) individuals (mean age: 58.5 ± 10.5 years; range: 40-94 years). Using two age limits (>55 years and 40+ years) for the definitions of RPD and AMD (age-related macular degeneration), RPD prevalence was 186/4914 (3.8%; 95% confidence interval (CI): 3.3, 4.3) and 246/4914 (5.0%, 95% CI: 4.4, 5.6), respectively, and the prevalence of any AMD without RPD was 182/4914 (3.7%: 95% CI: 3.2, 4.2) and 224/4914 (4.6%; 95% CI: 4.0, 5.1) respectively. Within the subgroup of early AMD, intermediate AMD and late AMD, RPD prevalence (age limit: 40+ years) was 55.1% (95% CI: 49.5, 60.8), 42.9% (95% CI: 33.8, 51.9) and 33.3% (95% CI: 16.4, 50.3) respectively. In multivariable analysis, higher RPD prevalence (age limit 40+ years) was associated with higher age (odds ratio (OR): 1.08; 95% CI: 1.07, 1.10; p < 0.001), rural region of habitation (OR: 3.81; 95% CI: 2.76, 5.24; p < 0.001) and lower percentage of lymphocytes on leukocyte counts (OR: 0.95; 95% CI: 0.93, 0.97; p < 0.001). Higher prevalence of any AMD without RPD was associated with urban region (OR: 1.58; 95% CI: 1.18, 2.11; p = 0.002), lower diabetes prevalence (OR: 0.55; 95% CI: 0.33, 0.90; p = 0.02) and shorter axial length (OR: 0.85; 95% CI: 0.74, 0.98; p = 0.03), after adjusting for age. Conclusions Reticular pseudodrusen (mean prevalence: 3.8% (age limit >55 years); 5.0% (age limit 40+ years)) differs from AMD without RPD in its association with urban region (AMD without RPD: rural region), lower lymphocyte percentage (AMD without RPD: no association) and a lack of associations with axial length (AMD without RPD: shorter axial length) and with diabetes prevalence (AMD without RPD: lower diabetes prevalence).
Item Description:Gesehen am 22.05.2023
Physical Description:Online Resource
ISSN:1755-3768
DOI:10.1111/aos.15145

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