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RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner

The receptor for advanced glycation endproducts, RAGE, is involved in the pathogenesis of many inflammatory conditions, which is mostly related to its strong activation of NF-κB but also due to its function as ligand for the β2-integrin Mac-1. To further dissect the stimulus-dependent role of RAGE o...

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Main Authors: Frommhold, David (Author) , Kamphues, Anna (Author) , Dannenberg, Susanne (Author) , Buschmann-Prayon, Kirsten (Author) , Zablotskaya, Victoria (Author) , Tschada, Raphaela (Author) , Lange-Sperandio, Baerbel (Author) , Nawroth, Peter Paul (Author) , Pöschl, Johannes (Author) , Bierhaus, Angelika (Author) , Sperandio, Markus (Author)
Format: Article (Journal)
Language:English
Published: 4 October 2011
In: BMC immunology
Year: 2011, Volume: 12, Pages: 1-12
ISSN:1471-2172
DOI:10.1186/1471-2172-12-56
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2172-12-56
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Author Notes:David Frommhold, Anna Kamphues, Susanne Dannenberg, Kirsten Buschmann, Victoria Zablotskaya, Raphaela Tschada, Baerbel Lange-Sperandio, Peter P. Nawroth, Johannes Poeschl, Angelika Bierhaus and Markus Sperandio
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Summary:The receptor for advanced glycation endproducts, RAGE, is involved in the pathogenesis of many inflammatory conditions, which is mostly related to its strong activation of NF-κB but also due to its function as ligand for the β2-integrin Mac-1. To further dissect the stimulus-dependent role of RAGE on leukocyte recruitment during inflammation, we investigated β2-integrin-dependent leukocyte adhesion in RAGE-/-and Icam1-/-mice in different cremaster muscle models of inflammation using intravital microscopy.
Item Description:Gesehen am 24.05.2023
Physical Description:Online Resource
ISSN:1471-2172
DOI:10.1186/1471-2172-12-56

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