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RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner

The receptor for advanced glycation endproducts, RAGE, is involved in the pathogenesis of many inflammatory conditions, which is mostly related to its strong activation of NF-κB but also due to its function as ligand for the β2-integrin Mac-1. To further dissect the stimulus-dependent role of RAGE o...

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Hauptverfasser: Frommhold, David (VerfasserIn) , Kamphues, Anna (VerfasserIn) , Dannenberg, Susanne (VerfasserIn) , Buschmann-Prayon, Kirsten (VerfasserIn) , Zablotskaya, Victoria (VerfasserIn) , Tschada, Raphaela (VerfasserIn) , Lange-Sperandio, Baerbel (VerfasserIn) , Nawroth, Peter Paul (VerfasserIn) , Pöschl, Johannes (VerfasserIn) , Bierhaus, Angelika (VerfasserIn) , Sperandio, Markus (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 4 October 2011
In: BMC immunology
Year: 2011, Jahrgang: 12, Pages: 1-12
ISSN:1471-2172
DOI:10.1186/1471-2172-12-56
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2172-12-56
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Verfasserangaben:David Frommhold, Anna Kamphues, Susanne Dannenberg, Kirsten Buschmann, Victoria Zablotskaya, Raphaela Tschada, Baerbel Lange-Sperandio, Peter P. Nawroth, Johannes Poeschl, Angelika Bierhaus and Markus Sperandio
Beschreibung
Zusammenfassung:The receptor for advanced glycation endproducts, RAGE, is involved in the pathogenesis of many inflammatory conditions, which is mostly related to its strong activation of NF-κB but also due to its function as ligand for the β2-integrin Mac-1. To further dissect the stimulus-dependent role of RAGE on leukocyte recruitment during inflammation, we investigated β2-integrin-dependent leukocyte adhesion in RAGE-/-and Icam1-/-mice in different cremaster muscle models of inflammation using intravital microscopy.
Beschreibung:Gesehen am 24.05.2023
Beschreibung:Online Resource
ISSN:1471-2172
DOI:10.1186/1471-2172-12-56

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