Intensity-modulated whole abdominal radiotherapy after surgery and carboplatin/taxane chemotherapy for advanced ovarian cancer: phase I study
Purpose - To assess the feasibility and toxicity of consolidative intensity-modulated whole abdominal radiotherapy (WAR) after surgery and chemotherapy in high-risk patients with advanced ovarian cancer. - Methods and Materials - Ten patients with optimally debulked ovarian cancer International Fede...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2010
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| In: |
International journal of radiation oncology, biology, physics
Year: 2010, Volume: 76, Issue: 5, Pages: 1382-1389 |
| ISSN: | 1879-355X |
| DOI: | 10.1016/j.ijrobp.2009.03.061 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijrobp.2009.03.061 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0360301609005744 
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| Author Notes: | Nathalie Rochet, M.D., Florian Sterzing, M.D., Alexandra D. Jensen, M.D., Julien Dinkel, M.D., Klaus K. Herfarth, M.D., Kai Schubert, Ph.D., Michael H. Eichbaum, M.D., Andreas Schneeweiss, M.D., Christof Sohn, M.D., Juergen Debus, M.D., Ph.D., and Wolfgang Harms, M.D. |
| Summary: | Purpose - To assess the feasibility and toxicity of consolidative intensity-modulated whole abdominal radiotherapy (WAR) after surgery and chemotherapy in high-risk patients with advanced ovarian cancer. - Methods and Materials - Ten patients with optimally debulked ovarian cancer International Federation of Gynecology and Obstetrics Stage IIIc were treated in a Phase I study with intensity-modulated WAR up to a total dose of 30 Gy in 1.5-Gy fractions as consolidation therapy after adjuvant carboplatin/taxane chemotherapy. Treatment was delivered using intensity-modulated radiotherapy in a step-and-shoot technique (n = 3) or a helical tomotherapy technique (n = 7). The planning target volume included the entire peritoneal cavity and the pelvic and para-aortal node regions. Organs at risk were kidneys, liver, heart, vertebral bodies, and pelvic bones. - Results - Intensity-modulated WAR resulted in an excellent coverage of the planning target volume and an effective sparing of the organs at risk. The treatment was well tolerated, and no severe Grade 4 acute side effects occurred. Common Toxicity Criteria Grade III toxicities were as follows: diarrhea (n = 1), thrombocytopenia (n = 1), and leukopenia (n = 3). Radiotherapy could be completed by all the patients without any toxicity-related interruption. Median follow-up was 23 months, and 4 patients had tumor recurrence (intraperitoneal progression, n = 3; hepatic metastasis, n = 1). Small bowel obstruction caused by adhesions occurred in 3 patients. - Conclusions - The results of this Phase I study showed for the first time, to our knowledge, the clinical feasibility of intensity-modulated whole abdominal radiotherapy, which could offer a new therapeutic option for consolidation treatment of advanced ovarian carcinoma after adjuvant chemotherapy in selected subgroups of patients. We initiated a Phase II study to further evaluate the toxicity of this intensive multimodal treatment. |
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| Item Description: | Erstmals am 21. Juli 2009 online veröffentlicht Gesehen am 25.05.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1879-355X |
| DOI: | 10.1016/j.ijrobp.2009.03.061 |