Performance of T-Track TB, a novel dual marker RT-qPCR-based whole-blood test for improved detection of active tuberculosis

Tuberculosis (TB) is one of the leading causes of death by an infectious disease. It remains a major health burden worldwide, in part due to misdiagnosis. Therefore, improved diagnostic tests allowing the faster and more reliable diagnosis of patients with active TB are urgently needed. This prospec...

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Hauptverfasser: Meier, Johannes (VerfasserIn) , Möbus, Selina (VerfasserIn) , Heigl, Florian (VerfasserIn) , Asbach-Nitzsche, Alexandra (VerfasserIn) , Niller, Hans Helmut (VerfasserIn) , Plentz, Annelie (VerfasserIn) , Avsar, Korkut (VerfasserIn) , Heiß-Neumann, Marion (VerfasserIn) , Schaaf, Bernhard (VerfasserIn) , Cassens, Uwe (VerfasserIn) , Seese, Bernd (VerfasserIn) , Teschner, Daniel (VerfasserIn) , Handzhiev, Sabin (VerfasserIn) , Graf, Uwe (VerfasserIn) , Lübbert, Christoph (VerfasserIn) , Steinmaurer, Monika (VerfasserIn) , Kontogianni, Konstantina (VerfasserIn) , Berg, Christoph (VerfasserIn) , Maieron, Andreas (VerfasserIn) , Blaas, Stefan H. (VerfasserIn) , Wagner, Ralf (VerfasserIn) , Deml, Ludwig (VerfasserIn) , Barabas, Sascha (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 16 February 2023
In: Diagnostics
Year: 2023, Jahrgang: 13, Heft: 4, Pages: 1-16
ISSN:2075-4418
DOI:10.3390/diagnostics13040758
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/diagnostics13040758
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2075-4418/13/4/758
Volltext
Verfasserangaben:Johannes P. Meier, Selina Möbus, Florian Heigl, Alexandra Asbach-Nitzsche, Hans Helmut Niller, Annelie Plentz, Korkut Avsar, Marion Heiß-Neumann, Bernhard Schaaf, Uwe Cassens, Bernd Seese, Daniel Teschner, Sabin Handzhiev, Uwe Graf, Christoph Lübbert, Monika Steinmaurer, Konstantina Kontogianni, Christoph Berg, Andreas Maieron, Stefan H. Blaas, Ralf Wagner, Ludwig Deml and Sascha Barabas
Beschreibung
Zusammenfassung:Tuberculosis (TB) is one of the leading causes of death by an infectious disease. It remains a major health burden worldwide, in part due to misdiagnosis. Therefore, improved diagnostic tests allowing the faster and more reliable diagnosis of patients with active TB are urgently needed. This prospective study examined the performance of the new molecular whole-blood test T-Track® TB, which relies on the combined evaluation of IFNG and CXCL10 mRNA levels, and compared it to that of the QuantiFERON®-TB Gold Plus (QFT-Plus) enzyme-linked immunosorbent assay (ELISA). ...
Beschreibung:Gesehen am 30.11.2023
Beschreibung:Online Resource
ISSN:2075-4418
DOI:10.3390/diagnostics13040758