BOLD responses in human auditory cortex are more closely related to transient MEG responses than to sustained ones
Blood oxygen level dependent-functional magnetic resonance imaging (BOLD-fMRI) and magnetoencephalographic (MEG) signals are both coupled to postsynaptic potentials, although their relationship is incompletely understood. Here, the wide range of BOLD-fMRI and MEG responses produced by auditory corte...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
27. January 27, 2010
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| In: |
Journal of neurophysiology
Year: 2010, Volume: 103, Issue: 4, Pages: 2015-2026 |
| ISSN: | 1522-1598 |
| DOI: | 10.1152/jn.01005.2009 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1152/jn.01005.2009 Verlag, lizenzpflichtig, Volltext: https://journals.physiology.org/doi/full/10.1152/jn.01005.2009 
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| Author Notes: | Alexander Gutschalk, Matti S. Hämäläinen, and Jennifer R. Melcher |
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| 520 | |a Blood oxygen level dependent-functional magnetic resonance imaging (BOLD-fMRI) and magnetoencephalographic (MEG) signals are both coupled to postsynaptic potentials, although their relationship is incompletely understood. Here, the wide range of BOLD-fMRI and MEG responses produced by auditory cortex was exploited to better understand the BOLD-fMRI/MEG relationship. Measurements of BOLD and MEG responses were made in the same subjects using the same stimuli for both modalities. The stimuli, 24-s sequences of click trains, had duty cycles of 2.5, 25, 72, and 100%. For the 2.5% sequence, the BOLD response was elevated throughout the sequence, whereas for 100%, it peaked after sequence onset and offset and showed a diminished elevation in between. On the finer timescale of MEG, responses at 2.5% consisted of a complex of transients, including N1m, to each click train of the sequence, whereas for 100% the only transients occurred at sequence onset and offset between which there was a sustained elevation in the MEG signal (a sustained field). A model that separately estimated the contributions of transient and sustained MEG signals to the BOLD response best fit BOLD measurements when the transient contribution was weighted 8- to 10-fold more than the sustained one. The findings suggest that BOLD responses in the auditory cortex are tightly coupled to the neural activity underlying transient, not sustained, MEG signals. | ||
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