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BOLD responses in human auditory cortex are more closely related to transient MEG responses than to sustained ones

Blood oxygen level dependent-functional magnetic resonance imaging (BOLD-fMRI) and magnetoencephalographic (MEG) signals are both coupled to postsynaptic potentials, although their relationship is incompletely understood. Here, the wide range of BOLD-fMRI and MEG responses produced by auditory corte...

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Bibliographische Detailangaben
Hauptverfasser: Gutschalk, Alexander (VerfasserIn) , Hämäläinen, Matti (VerfasserIn) , Melcher, Jennifer R. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 27. January 27, 2010
In: Journal of neurophysiology
Year: 2010, Jahrgang: 103, Heft: 4, Pages: 2015-2026
ISSN:1522-1598
DOI:10.1152/jn.01005.2009
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1152/jn.01005.2009
Verlag, lizenzpflichtig, Volltext: https://journals.physiology.org/doi/full/10.1152/jn.01005.2009
Volltext
Verfasserangaben:Alexander Gutschalk, Matti S. Hämäläinen, and Jennifer R. Melcher
Beschreibung
Zusammenfassung:Blood oxygen level dependent-functional magnetic resonance imaging (BOLD-fMRI) and magnetoencephalographic (MEG) signals are both coupled to postsynaptic potentials, although their relationship is incompletely understood. Here, the wide range of BOLD-fMRI and MEG responses produced by auditory cortex was exploited to better understand the BOLD-fMRI/MEG relationship. Measurements of BOLD and MEG responses were made in the same subjects using the same stimuli for both modalities. The stimuli, 24-s sequences of click trains, had duty cycles of 2.5, 25, 72, and 100%. For the 2.5% sequence, the BOLD response was elevated throughout the sequence, whereas for 100%, it peaked after sequence onset and offset and showed a diminished elevation in between. On the finer timescale of MEG, responses at 2.5% consisted of a complex of transients, including N1m, to each click train of the sequence, whereas for 100% the only transients occurred at sequence onset and offset between which there was a sustained elevation in the MEG signal (a sustained field). A model that separately estimated the contributions of transient and sustained MEG signals to the BOLD response best fit BOLD measurements when the transient contribution was weighted 8- to 10-fold more than the sustained one. The findings suggest that BOLD responses in the auditory cortex are tightly coupled to the neural activity underlying transient, not sustained, MEG signals.
Beschreibung:Gesehen am 02.06.2023
Beschreibung:Online Resource
ISSN:1522-1598
DOI:10.1152/jn.01005.2009

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