Carbon ion radiation therapy for high-risk meningiomas
BACKGROUND: We analyzed outcome after a carbon ion boost in combination with precision photon radiation therapy in patients with meningiomas. - PATIENTS AND METHODS: Ten patients with meningiomas were treated with carbon ion RT as part of a Phase I/II trial. Carbon ion RT was conducted in conjunctio...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 February 2010
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| In: |
Radiotherapy and oncology
Year: 2010, Volume: 95, Issue: 1, Pages: 54-59 |
| ISSN: | 1879-0887 |
| DOI: | 10.1016/j.radonc.2009.12.029 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.radonc.2009.12.029
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| Author Notes: | Stephanie E. Combs, Christian Hartmann, Anna Nikoghosyan, Oliver Jäkel, Christian P. Karger, Thomas Haberer, Andreas von Deimling, Marc W. Münter, Peter E. Huber, Jürgen Debus, Daniela Schulz-Ertner |
| Summary: | BACKGROUND: We analyzed outcome after a carbon ion boost in combination with precision photon radiation therapy in patients with meningiomas. - PATIENTS AND METHODS: Ten patients with meningiomas were treated with carbon ion RT as part of a Phase I/II trial. Carbon ion RT was conducted in conjunction with fractionated stereotactic RT (FSRT) or intensity-modulated RT (IMRT). Eight patients were treated as primary RT, in 2 patients carbon ion RT was performed as re-irradiation. Carbon ion RT was applied with a median dose of 18 GyE, and photon RT was applied with a median dose of 50.4 Gy. Two patients with a history of former irradiation received 18GyE of carbon ion RT and a reduced dose of photon treatment. - RESULTS: The median follow-up time was 77 months. Five patients died during follow-up, of which four died of tumor progression. In the group treated in the primary situation, actuarial survival rates after RT were 75% and 63% at 5 and 7 years. After re-irradiation, both patients died at 10 and 67 months, respectively. Actuarial local control rates after primary RT were 86% and 72% at 5 and 7 years. Two patients developed tumor recurrence after re-irradiation, 6 and 67 months after treatment. - CONCLUSION: In conclusion, carbon ion radiation shows promising results in patients with atypical or anaplastic meningiomas. Further evaluation in a larger, prospective study in comparison to proton RT or modern photon RT is needed to corroborate these results. |
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| Item Description: | Gesehen am 05.06.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1879-0887 |
| DOI: | 10.1016/j.radonc.2009.12.029 |