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The FRESH study: treatment of intracranial aneurysms with the new FRED X flow diverter with antithrombotic surface treatment technology - first multicenter experience in 161 patients

BACKGROUND AND PURPOSE: Flow diverters with antithrombotic coatings are increasingly used to improve the safety of flow diverter treatments of intracranial aneurysms. This study aimed to investigate the safety and short-term efficacy of the new FRED X flow diverter. - MATERIALS AND METHODS: Medical...

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Main Authors: Vollherbst, Dominik (Author) , Lücking, H. (Author) , DuPlessis, J. (Author) , Sonnberger, M. (Author) , Maurer, C. (Author) , Kocer, N. (Author) , Killer-Oberpfalzer, M. (Author) , Rautio, R. (Author) , Valvassori, L. (Author) , Berlis, A. (Author) , Gasser, S. (Author) , Gatt, S. (Author) , Dörfler, A. (Author) , Bendszus, Martin (Author) , Möhlenbruch, Markus Alfred (Author)
Format: Article (Journal)
Language:English
Published: April 10, 2023
In: American journal of neuroradiology
Year: 2023, Volume: 44, Issue: 4, Pages: 474-480
ISSN:1936-959X
DOI:10.3174/ajnr.A7834
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3174/ajnr.A7834
Verlag, lizenzpflichtig, Volltext: https://www.ajnr.org/content/44/4/474
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Author Notes:D.F. Vollherbst, H. Lücking, J. DuPlessis, M. Sonnberger, C. Maurer, N. Kocer, M. Killer-Oberpfalzer, R. Rautio, L. Valvassori, A. Berlis, S. Gasser, S. Gatt, A. Dörfler, M. Bendszus, and M.A. Möhlenbruch
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Summary:BACKGROUND AND PURPOSE: Flow diverters with antithrombotic coatings are increasingly used to improve the safety of flow diverter treatments of intracranial aneurysms. This study aimed to investigate the safety and short-term efficacy of the new FRED X flow diverter. - MATERIALS AND METHODS: Medical charts and procedural and imaging data of a consecutive series of patients with intracranial aneurysms who were treated with the FRED X at 9 international neurovascular centers were retrospectively analyzed. - RESULTS: One hundred sixty-one patients (77.6% women; mean age, 55 years) with 184 aneurysms (11.2% acutely ruptured) were included in this study. Most aneurysms were located in the anterior circulation (77.0%), most frequently at the ICA (72.7%). The FRED X was successfully implanted in all procedures. Additional coiling was performed in 29.8%. In-stent balloon angioplasty was necessary in 2.5%. The rate of major adverse events was 3.1%. Thrombotic events occurred in 7 patients (4.3%) with 4 intra- and 4 postprocedural in-stent thromboses, respectively (1 patient had both peri- and postprocedural thrombosis). Of these thrombotic events, only 2 (1.2%) led to major adverse events (ischemic strokes). Postinterventional neurologic morbidity and mortality were observed in 1.9% and 1.2%, respectively. The rate of complete aneurysm occlusion after a mean follow-up of 7.0 months was 66.0%. - CONCLUSIONS: The new FRED X is a safe and feasible device for aneurysm treatment. In this retrospective multicenter study, the rate of thrombotic complications was low, and the short-term occlusion rates are satisfactory.
Item Description:Gesehen am 06.06.2023
Physical Description:Online Resource
ISSN:1936-959X
DOI:10.3174/ajnr.A7834

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