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Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study

The Associazione Italiana di Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Münster Acute Lymphoblastic Leukemia (AIEOP-BFM ALL 2000) study has for the first time introduced standardized quantitative assessment of minimal residual disease (MRD) based on immunoglobulin and T-cell receptor...

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Autori principali: Conter, Valentino (Autore) , Bartram, Claus R. (Autore) , Valsecchi, Maria Grazia (Autore) , Schrauder, André (Autore) , Panzer-Grümayer, Renate (Autore) , Möricke, Anja (Autore) , Aricò, Maurizio (Autore) , Zimmermann, Martin (Autore) , Mann, Georg (Autore) , De Rossi, Giulio (Autore) , Stanulla, Martin (Autore) , Locatelli, Franco (Autore) , Basso, Giuseppe (Autore) , Niggli, Felix (Autore) , Barisone, Elena (Autore) , Henze, Günter (Autore) , Ludwig, Wolf-Dieter (Autore) , Haas, Oskar A. (Autore) , Cazzaniga, Giovanni (Autore) , Köhler, Rolf (Autore) , Silvestri, Daniela (Autore) , Bradtke, Jutta (Autore) , Parasole, Rosanna (Autore) , Beier, Rita (Autore) , van Dongen, Jacques J. M. (Autore) , Biondi, Andrea (Autore) , Schrappe, Martin (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: 14 December 2020
In: Blood
Year: 2010, Volume: 115, Fascicolo: 16, Pages: 3206-3214
ISSN:1528-0020
DOI:10.1182/blood-2009-10-248146
Accesso online:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood-2009-10-248146
Testo
Note sull'autore:Valentino Conter, Claus R. Bartram, Maria Grazia Valsecchi, André Schrauder, Renate Panzer-Grümayer, Anja Möricke, Maurizio Aricò, Martin Zimmermann, Georg Mann, Giulio De Rossi, Martin Stanulla, Franco Locatelli, Giuseppe Basso, Felix Niggli, Elena Barisone, Günter Henze, Wolf-Dieter Ludwig, Oskar A. Haas, Giovanni Cazzaniga, Rolf Koehler, Daniela Silvestri, Jutta Bradtke, Rosanna Parasole, Rita Beier, Jacques J.M. van Dongen, Andrea Biondi, and Martin Schrappe
Descrizione
Riassunto:The Associazione Italiana di Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Münster Acute Lymphoblastic Leukemia (AIEOP-BFM ALL 2000) study has for the first time introduced standardized quantitative assessment of minimal residual disease (MRD) based on immunoglobulin and T-cell receptor gene rearrangements as polymerase chain reaction targets (PCR-MRD), at 2 time points (TPs), to stratify patients in a large prospective study. Patients with precursor B (pB) ALL (n = 3184) were considered MRD standard risk (MRD-SR) if MRD was already negative at day 33 (analyzed by 2 markers, with a sensitivity of at least 10(-4)); MRD high risk (MRD-HR) if 10(-3) or more at day 78 and MRD intermediate risk (MRD-IR): others. MRD-SR patients were 42% (1348): 5-year event-free survival (EFS, standard error) is 92.3% (0.9). Fifty-two percent (1647) were MRD-IR: EFS 77.6% (1.3). Six percent of patients (189) were MRD-HR: EFS 50.1% (4.1; P < .001). PCR-MRD discriminated prognosis even on top of white blood cell count, age, early response to prednisone, and genotype. MRD response detected by sensitive quantitative PCR at 2 predefined TPs is highly predictive for relapse in childhood pB-ALL. The study is registered at http://clinicaltrials.gov: NCT00430118 for BFM and NCT00613457 for AIEOP.
Descrizione del documento:Gesehen am 06.06.2023
Descrizione fisica:Online Resource
ISSN:1528-0020
DOI:10.1182/blood-2009-10-248146

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