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Treatment of locally advanced carcinomas of head and neck with intensity-modulated radiation therapy (IMRT) in combination with cetuximab and chemotherapy: the REACH protocol

Primary treatment of carcinoma of the oro-/hypopharynx or larynx may consist of combined platinum-containing chemoradiotherapy. In order to improve clinical outcome (i.e. local control/overall survival), combined therapy is intensified by the addition of the EGFR inhibitor cetuximab (Erbitux®). Radi...

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Main Authors: Habl, Gregor (Author) , Jensen, Alexandra (Author) , Potthoff, Karin (Author) , Uhl, Matthias (Author) , Hof, Holger (Author) , Hajda, Jacek (Author) , Simon, Christian (Author) , Debus, Jürgen (Author) , Krempien, Robert (Author) , Münter, Marc (Author)
Format: Article (Journal)
Language:English
Published: 26 November 2010
In: BMC cancer
Year: 2010, Volume: 10, Pages: 1-8
ISSN:1471-2407
DOI:10.1186/1471-2407-10-651
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1471-2407-10-651
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Author Notes:Gregor Habl, Alexandra D. Jensen, Karin Potthoff, Matthias Uhl, Holger Hof, Jacek Hajda, Christian Simon, Jürgen Debus, Robert Krempien, Marc W. Münter
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Summary:Primary treatment of carcinoma of the oro-/hypopharynx or larynx may consist of combined platinum-containing chemoradiotherapy. In order to improve clinical outcome (i.e. local control/overall survival), combined therapy is intensified by the addition of the EGFR inhibitor cetuximab (Erbitux®). Radiation therapy (RT) is carried out as intensity-modulated RT (IMRT) to avoid higher grade acute and late toxicity by sparing of surrounding normal tissues.
Item Description:Gesehen am 09.06.2023
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/1471-2407-10-651

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