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D-dimer levels in non-COVID-19 ARDS and COVID-19 ARDS patients: a systematic review with meta-analysis

Background Hypercoagulability and thrombo-inflammation are the main reasons for death in COVID-19 patients. It is unclear whether there is a difference between D-dimer levels in patients without or with COVID-19 acute respiratory distress syndrome (ARDS). Methods We searched PubMed, EMBASE, and Clin...

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Main Authors: Tóth, Krisztina (Author) , Fresilli, Stefano (Author) , Paoli, Nicola (Author) , Maiucci, Giacomo (Author) , Salvioni, Mariateresa (Author) , Kotani, Yuki (Author) , Katzenschlager, Stephan (Author) , Weigand, Markus A. (Author) , Landoni, Giovanni (Author)
Format: Article (Journal)
Language:English
Published: February 6, 2023
In: PLOS ONE
Year: 2023, Volume: 18, Issue: 2, Pages: 1-10
ISSN:1932-6203
DOI:10.1371/journal.pone.0277000
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1371/journal.pone.0277000
Verlag, kostenfrei, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0277000
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Author Notes:Krisztina Tóth, Stefano Fresilli, Nicola Paoli, Giacomo Maiucci, Mariateresa Salvioni, Yuki Kotani, Stephan Katzenschlager, Markus A. Weigand, Giovanni Landoni
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Summary:Background Hypercoagulability and thrombo-inflammation are the main reasons for death in COVID-19 patients. It is unclear whether there is a difference between D-dimer levels in patients without or with COVID-19 acute respiratory distress syndrome (ARDS). Methods We searched PubMed, EMBASE, and ClinicalTrails.gov databases looking for studies reporting D-dimer levels in patients without or with COVID-19 ARDS. Secondary endpoints included length of hospital stay, and mortality data at the longest follow-up available. Results We included 12 retrospective and 3 prospective studies with overall 2,828 patients, of whom 1,404 (49.6%) had non-COVID-19 ARDS and 1,424 had COVID-19 ARDS. D-dimer levels were not significantly higher in non-COVID-19 ARDS than in COVID-19 ARDS patients (mean 7.65 mg/L vs. mean 6.20 mg/L MD 0.88 [CI: -0.61 to 2.38] p = 0.25; I² = 85%) while the length of hospital stay was shorter (non-COVID-19 mean 37.4 days vs. COVID-19 mean 48.5 days, MD -10.92 [CI: -16.71 to -5.14] p < 0.001; I² = 44%). No difference in mortality was observed: non-COVID-19 ARDS 418/1167 (35.8%) vs. COVID-19 ARDS 467/1201 (38.8%). Conclusions We found no difference in the mean D-dimer levels between non-COVID-19 ARDS and COVID-19 ARDS patients.
Item Description:Gesehen am 12.06.2023
Physical Description:Online Resource
ISSN:1932-6203
DOI:10.1371/journal.pone.0277000

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