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Asynchronous calibration of quantitative computed tomography bone mineral density assessment for opportunistic osteoporosis screening: phantom-based validation and parameter influence evaluation

Asynchronous calibration could allow opportunistic screening based on routine CT for early osteoporosis detection. In this phantom study, a bone mineral density (BMD) calibration phantom and multi-energy CT (MECT) phantom were imaged on eight different CT scanners with multiple tube voltages (80-150...

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Main Authors: Skornitzke, Stephan (Author) , Vats, Neha (Author) , Kopytova, Taisiya G. (Author) , Tong, Elizabeth Wai Yee (Author) , Hofbauer, Tobias (Author) , Weber, Tim (Author) , Rehnitz, Christoph (Author) , Stackelberg, Oyunbileg von (Author) , Maier-Hein, Klaus H. (Author) , Stiller, Wolfram (Author) , Biederer, Jürgen (Author) , Kauczor, Hans-Ulrich (Author) , Heußel, Claus Peter (Author) , Wielpütz, Mark Oliver (Author) , Palm, Viktoria (Author)
Format: Article (Journal)
Language:English
Published: 01 December 2022
In: Scientific reports
Year: 2022, Volume: 12, Pages: 1-9
ISSN:2045-2322
DOI:10.1038/s41598-022-24546-2
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41598-022-24546-2
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-022-24546-2
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Author Notes:Stephan Skornitzke, Neha Vats, Taisiya Kopytova, Elizabeth Wai Yee Tong, Tobias Hofbauer, Tim Frederik Weber, Christoph Rehnitz, Oyunbileg von Stackelberg, Klaus Maier-Hein, Wolfram Stiller, Jürgen Biederer, Hans-Ulrich Kauczor, Claus-Peter Heußel, Mark Wielpütz & Viktoria Palm
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Summary:Asynchronous calibration could allow opportunistic screening based on routine CT for early osteoporosis detection. In this phantom study, a bone mineral density (BMD) calibration phantom and multi-energy CT (MECT) phantom were imaged on eight different CT scanners with multiple tube voltages (80-150 kVp) and image reconstruction settings (e.g. soft/hard kernel). Reference values for asynchronous BMD estimation were calculated from the BMD-phantom and validated with six calcium composite inserts of the MECT-phantom with known ground truth. Relative errors/changes in estimated BMD were calculated and investigated for influence of tube voltage, CT scanner and reconstruction setting. Reference values for 282 acquisitions were determined, resulting in an average relative error between calculated BMD and ground truth of − 9.2% ± 14.0% with a strong correlation (R2 = 0.99; p < 0.0001). Tube voltage and CT scanner had a significant effect on calculated BMD (p < 0.0001), with relative differences in BMD of 3.8% ± 28.2% when adapting reference values for tube voltage, − 5.6% ± 9.2% for CT scanner and 0.2% ± 0.2% for reconstruction setting, respectively. Differences in BMD were small when using reference values from a different CT scanner of the same model (0.0% ± 1.4%). Asynchronous phantom-based calibration is feasible for opportunistic BMD assessment based on CT images with reference values adapted for tube voltage and CT scanner model.
Item Description:Gesehen am 12.06.2023
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-022-24546-2

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