Cover Image

Circulating tumour cells in patients with lung cancer universally indicate poor prognosis: review

Background: In lung cancer, the relevance of various circulating tumour cell (CTC) subgroups in different lung cancer subtypes is unclear. We performed a comprehensive meta-analysis to assess the prognostic value of CTCs in the different histological types of lung cancer, with particular respect to...

Full description

Saved in:
Bibliographic Details
Main Authors: Jin, Fukang (Author) , Zhu, Lei (Author) , Shao, Jingbo (Author) , Yakoub, Mina (Author) , Schmitt, Lukas (Author) , Reißfelder, Christoph (Author) , Loges, Sonja (Author) , Benner, Axel (Author) , Schölch, Sebastian (Author)
Format: Article (Journal)
Language:English
Published: December 14, 2022
In: European respiratory review
Year: 2022, Volume: 31, Issue: 166, Pages: 1-14
ISSN:1600-0617
DOI:10.1183/16000617.0151-2022
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1183/16000617.0151-2022
Verlag, kostenfrei, Volltext: http://err.ersjournals.com/content/31/166/220151
Get full text
Author Notes:Fukang Jin, Lei Zhu, Jingbo Shao, Mina Yakoub, Lukas Schmitt, Christoph Reißfelder, Sonja Loges, Axel Benner and Sebastian Schölch
Description
Summary:Background: In lung cancer, the relevance of various circulating tumour cell (CTC) subgroups in different lung cancer subtypes is unclear. We performed a comprehensive meta-analysis to assess the prognostic value of CTCs in the different histological types of lung cancer, with particular respect to CTC subtypes, cut-offs and time points of CTC enumeration. - Methods: We searched MEDLINE, Web of Science and Embase alongside relevant studies evaluating the prognostic value of CTCs in lung cancer patients. A random-effects model was used for meta-analysis, calculating hazard ratios (HRs), 95% confidence intervals and p-values. - Results: 27 studies enrolling 2957 patients were included. CTC detection indicates poor prognosis, especially in small cell lung cancer (SCLC) patients (overall survival HR 3.11, 95% CI 2.59-3.73) and predicts a worse outcome compared to nonsmall cell lung cancer patients. Epithelial CTCs predict a worse outcome for lung cancer than mesenchymal CTCs or epithelial-mesenchymal hybrids. - Conclusion: CTCs indicate poor prognosis in patients with primary lung cancer, with CTCs in SCLC having a more pronounced prognostic effect. The prognostic value of CTCs detected by different markers varies; most evidence is available for the strong negative prognostic effect of epithelial CTCs. - Tweetable abstract ERSpublications - click to tweetThis meta-analysis demonstrates that the prognostic value of epithelial CTCs is greater than that of mesenchymal CTCs in lung cancer. CTCs indicate poor prognosis in all subtypes of lung cancer; this effect increases with CTC detection thresholds. https://bit.ly/3dhlY0C
Item Description:Gesehen am 12.06.2023
Physical Description:Online Resource
ISSN:1600-0617
DOI:10.1183/16000617.0151-2022

Similar Items