Circulating tumour cells in patients with lung cancer universally indicate poor prognosis: review
Background: In lung cancer, the relevance of various circulating tumour cell (CTC) subgroups in different lung cancer subtypes is unclear. We performed a comprehensive meta-analysis to assess the prognostic value of CTCs in the different histological types of lung cancer, with particular respect to...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 14, 2022
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| In: |
European respiratory review
Year: 2022, Jahrgang: 31, Heft: 166, Pages: 1-14 |
| ISSN: | 1600-0617 |
| DOI: | 10.1183/16000617.0151-2022 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1183/16000617.0151-2022 Verlag, kostenfrei, Volltext: http://err.ersjournals.com/content/31/166/220151 
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| Verfasserangaben: | Fukang Jin, Lei Zhu, Jingbo Shao, Mina Yakoub, Lukas Schmitt, Christoph Reißfelder, Sonja Loges, Axel Benner and Sebastian Schölch |
| Zusammenfassung: | Background: In lung cancer, the relevance of various circulating tumour cell (CTC) subgroups in different lung cancer subtypes is unclear. We performed a comprehensive meta-analysis to assess the prognostic value of CTCs in the different histological types of lung cancer, with particular respect to CTC subtypes, cut-offs and time points of CTC enumeration. - Methods: We searched MEDLINE, Web of Science and Embase alongside relevant studies evaluating the prognostic value of CTCs in lung cancer patients. A random-effects model was used for meta-analysis, calculating hazard ratios (HRs), 95% confidence intervals and p-values. - Results: 27 studies enrolling 2957 patients were included. CTC detection indicates poor prognosis, especially in small cell lung cancer (SCLC) patients (overall survival HR 3.11, 95% CI 2.59-3.73) and predicts a worse outcome compared to nonsmall cell lung cancer patients. Epithelial CTCs predict a worse outcome for lung cancer than mesenchymal CTCs or epithelial-mesenchymal hybrids. - Conclusion: CTCs indicate poor prognosis in patients with primary lung cancer, with CTCs in SCLC having a more pronounced prognostic effect. The prognostic value of CTCs detected by different markers varies; most evidence is available for the strong negative prognostic effect of epithelial CTCs. - Tweetable abstract ERSpublications - click to tweetThis meta-analysis demonstrates that the prognostic value of epithelial CTCs is greater than that of mesenchymal CTCs in lung cancer. CTCs indicate poor prognosis in all subtypes of lung cancer; this effect increases with CTC detection thresholds. https://bit.ly/3dhlY0C |
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| Beschreibung: | Gesehen am 12.06.2023 |
| Beschreibung: | Online Resource |
| ISSN: | 1600-0617 |
| DOI: | 10.1183/16000617.0151-2022 |