Impact of HLA mismatching on incidence of posttransplant non-Hodgkin lymphoma after kidney transplantation
Background. - Posttransplant non-Hodgkin lymphoma is a rare complication but associated with high mortality. The extent to which human leukocyte antigen (HLA) mismatching influences the rate of posttransplant lymphoma has not been clarified. - Methods. - Data on lymphomas occurring in the first 3 ye...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2010
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| In: |
Transplantation
Year: 2010, Volume: 89, Issue: 5, Pages: 567-572 |
| ISSN: | 1534-6080 |
| DOI: | 10.1097/TP.0b013e3181c69855 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/TP.0b013e3181c69855 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/transplantjournal/Fulltext/2010/03150/Impact_of_HLA_Mismatching_on_Incidence_of.10.aspx 
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| Author Notes: | Gerhard Opelz and Bernd Döhler |
| Summary: | Background. - Posttransplant non-Hodgkin lymphoma is a rare complication but associated with high mortality. The extent to which human leukocyte antigen (HLA) mismatching influences the rate of posttransplant lymphoma has not been clarified. - Methods. - Data on lymphomas occurring in the first 3 years posttransplant were analyzed among first kidney transplants from deceased donors performed between 1985 and 2007 and reported to the Collaborative Transplant Study. - Results. -Of 152,728 patients included, 593 non-Hodgkin lymphomas were diagnosed. Cox multivariate regression analysis showed that HLA-A mismatches had no influence on the rate of lymphoma. One and two HLA-DR mismatches were associated with a hazard ratio (HR) of 1.21 (95% confidence interval 1.00-1.45, P=0.047) and 1.56 (95% confidence interval 1.21-1.99, P<0.001), respectively. For lymphoma of the kidney and central nervous system, HRs for two HLA-DR mismatches were 2.29 (P=0.007) and 2.17 (P=0.029), respectively. Two HLA-B mismatches were also significantly associated with lymphoma in the kidney (HR 2.82, P=0.009). - Conclusion. - Mismatches at the HLA-DR locus are a significant risk factor for posttransplant non-Hodgkin lymphoma, particularly in the kidney and central nervous system, whereas two HLA-B mismatches increase the risk for the development of lymphoma of the kidney. |
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| Item Description: | Gesehen am 14.06.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1534-6080 |
| DOI: | 10.1097/TP.0b013e3181c69855 |