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Multi-omics signatures in new-onset diabetes predict metabolic response to dietary inulin: findings from an observational study followed by an interventional trial

The metabolic performance of the gut microbiota contributes to the onset of type 2 diabetes. However, targeted dietary interventions are limited by the highly variable inter-individual response. We hypothesized (1) that the composition of the complex gut microbiome and metabolome (MIME) differ acros...

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Main Authors: Ďásková, Nikola (Author) , Modos, I. (Author) , Krbcová, M. (Author) , Kuzma, M. (Author) , Pelantová, H. (Author) , Hradecký, J. (Author) , Heczková, M. (Author) , Bratová, M. (Author) , Videňská, P. (Author) , Šplíchalová, P. (Author) , Králová, M. (Author) , Heniková, M. (Author) , Potočková, J. (Author) , Ouřadová, A. (Author) , Landberg, R. (Author) , Kühn, Tilman (Author) , Cahová, M. (Author) , Gojda, J. (Author)
Format: Article (Journal)
Language:English
Published: 21 April 2023
In: Nutrition & Diabetes
Year: 2023, Volume: 13, Pages: 1-13
ISSN:2044-4052
DOI:10.1038/s41387-023-00235-5
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41387-023-00235-5
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41387-023-00235-5
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Author Notes:N. Ďásková, I. Modos, M. Krbcová, M. Kuzma, H. Pelantová, J. Hradecký, M. Heczková, M. Bratová, P. Videňská, P. Šplíchalová, M. Králová, M. Heniková, J. Potočková, A. Ouřadová, R. Landberg, T. Kühn, M. Cahová and J. Gojda
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Summary:The metabolic performance of the gut microbiota contributes to the onset of type 2 diabetes. However, targeted dietary interventions are limited by the highly variable inter-individual response. We hypothesized (1) that the composition of the complex gut microbiome and metabolome (MIME) differ across metabolic spectra (lean-obese-diabetes); (2) that specific MIME patterns could explain the differential responses to dietary inulin; and (3) that the response can be predicted based on baseline MIME signature and clinical characteristics.
Item Description:Gesehen am 15.06.2023
Physical Description:Online Resource
ISSN:2044-4052
DOI:10.1038/s41387-023-00235-5

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