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Lipid based therapy for ulcerative colitis: modulation of intestinal mucus membrane phospholipids as a tool to influence inflammation

Ulcerative colitis (UC) is the result of an inappropriate colonic inflammatory response triggered by environmental and genetic factors. We have recently shown that mucus from UC patients has a decreased phosphatidylcholine (PC) content, while clinical trials revealed that therapeutic addition of PC...

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Bibliographic Details
Main Authors: Schneider, Hannah (Author) , Gauss, Annika (Author) , Füllekrug, Joachim (Author) , Stremmel, Wolfgang (Author) , Ehehalt, Robert (Author)
Format: Article (Journal)
Language:English
Published: 25 October 2010
In: International journal of molecular sciences
Year: 2010, Volume: 11, Issue: 10, Pages: 4149-4164
ISSN:1422-0067
DOI:10.3390/ijms11104149
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.3390/ijms11104149
Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/11/10/4149
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Author Notes:Hannah Schneider, Annika Braun, Joachim Füllekrug, Wolfgang Stremmel and Robert Ehehalt
Description
Summary:Ulcerative colitis (UC) is the result of an inappropriate colonic inflammatory response triggered by environmental and genetic factors. We have recently shown that mucus from UC patients has a decreased phosphatidylcholine (PC) content, while clinical trials revealed that therapeutic addition of PC to the colonic mucus alleviated the inflammatory activity. The mechanisms behind this are still unclear.
Item Description:Gesehen am 20.06.2023
Physical Description:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms11104149

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