Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury

Liver ischemia/reperfusion (I/R) injury is a frequent cause of organ dysfunction. Loss of the oxygen sensor prolyl hydroxylase domain enzyme 1 (PHD1) causes tolerance of skeletal muscle to hypoxia. We assessed whether loss or short-term silencing of PHD1 could likewise induce hypoxia tolerance in he...

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Main Authors:	Schneider, Martin (Author) , Van Geyte, Katie (Author) , Fraisl, Peter (Author) , Kiss, Judit (Author) , Aragonés, Julián (Author) , Mazzone, Massimiliano (Author) , Mairbäurl, Heimo (Author) , De Bock, Katrien (Author) , Jeoung, Nam Ho (Author) , Mollenhauer, Martin (Author) , Georgiadou, Maria (Author) , Bishop, Tammie (Author) , Roncal, Carmen (Author) , Sutherland, Andrew (Author) , Jordan, Benedicte (Author) , Gallez, Bernard (Author) , Weitz, Jürgen (Author) , Harris, Robert A. (Author) , Maxwell, Patrick (Author) , Baes, Myriam (Author) , Ratcliffe, Peter (Author) , Carmeliet, Peter (Author)
Format:	Article (Journal)
Language:	English
Published:	2010
In:	Gastroenterology Year: 2010, Volume: 138, Issue: 3, Pages: 1143-1154.e2
ISSN:	1528-0012
DOI:	10.1053/j.gastro.2009.09.057
Online Access:	Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1053/j.gastro.2009.09.057 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0016508509017521
Author Notes:	Martin Schneider, Katie Van Geyte, Peter Fraisl, Judit Kiss, Julián Aragonés, Massimiliano Mazzone, Heimo Mairbäurl, Katrien De Bock, Nam Ho Jeoung, Martin Mollenhauer, Maria Georgiadou, Tammie Bishop, Carmen Roncal, Andrew Sutherland, Benedicte Jordan, Bernard Gallez, Jürgen Weitz, Robert A. Harris, Patrick Maxwell, Myriam Baes, Peter Ratcliffe, and Peter Carmeliet