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OBERON3 and SUPPRESSOR of MAX2 1-like proteins form a regulatory module driving phloem development

Spatial specificity of cell fate decisions is central for organismal development. The phloem tissue mediates long-distance transport of energy metabolites along plant bodies and is characterized by an exceptional degree of cellular specialization. How a phloem-specific developmental program is imple...

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Main Authors: Wallner, Eva-Sophie (Author) , Tonn, Nina (Author) , Shi, Dongbo (Author) , Luzzietti, Laura (Author) , Wanke, Friederike (Author) , Hunziker, Pascal (Author) , Xu, Yingqiang (Author) , Jung, Ilona (Author) , Lopéz-Salmerón, Vadir (Author) , Gebert, Michael (Author) , Wenzl, Christian (Author) , Lohmann, Jan U. (Author) , Harter, Klaus (Author) , Greb, Thomas (Author)
Format: Article (Journal)
Language:English
Published: 14 April 2023
In: Nature Communications
Year: 2023, Volume: 14, Pages: 1-16
ISSN:2041-1723
DOI:10.1038/s41467-023-37790-5
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-023-37790-5
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-023-37790-5
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Author Notes:Eva-Sophie Wallner, Nina Tonn, Dongbo Shi, Laura Luzzietti, Friederike Wanke, Pascal Hunziker, Yingqiang Xu, Ilona Jung, Vadir Lopéz-Salmerón, Michael Gebert, Christian Wenzl, Jan U. Lohmann, Klaus Harter & Thomas Greb
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Summary:Spatial specificity of cell fate decisions is central for organismal development. The phloem tissue mediates long-distance transport of energy metabolites along plant bodies and is characterized by an exceptional degree of cellular specialization. How a phloem-specific developmental program is implemented is, however, unknown. Here we reveal that the ubiquitously expressed PHD-finger protein OBE3 forms a central module with the phloem-specific SMXL5 protein for establishing the phloem developmental program in Arabidopsis thaliana. By protein interaction studies and phloem-specific ATAC-seq analyses, we show that OBE3 and SMXL5 proteins form a complex in nuclei of phloem stem cells where they promote a phloem-specific chromatin profile. This profile allows expression of OPS, BRX, BAM3, and CVP2 genes acting as mediators of phloem differentiation. Our findings demonstrate that OBE3/SMXL5 protein complexes establish nuclear features essential for determining phloem cell fate and highlight how a combination of ubiquitous and local regulators generate specificity of developmental decisions in plants.
Item Description:Gesehen am 21.06.2023
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-023-37790-5

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