Computational modeling of cambium activity provides a regulatory framework for simulating radial plant growth
Precise organization of growing structures is a fundamental process in developmental biology. In plants, radial growth is mediated by the cambium, a stem cell niche continuously producing wood (xylem) and bast (phloem) in a strictly bidirectional manner. While this process contributes large parts to...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
10 March 2023
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| In: |
eLife
Year: 2023, Volume: 12, Pages: 1-37 |
| ISSN: | 2050-084X |
| DOI: | 10.7554/eLife.66627 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.7554/eLife.66627
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| Author Notes: | Ivan Lebovka, Bruno Hay Mele, Xiaomin Liu, Alexandra Zakieva, Theresa Schlamp, Nial Rau Gursanscky, Roeland MH Merks, Ruth Großeholz, Thomas Greb |
| Summary: | Precise organization of growing structures is a fundamental process in developmental biology. In plants, radial growth is mediated by the cambium, a stem cell niche continuously producing wood (xylem) and bast (phloem) in a strictly bidirectional manner. While this process contributes large parts to terrestrial biomass, cambium dynamics eludes direct experimental access due to obstacles in live-cell imaging. Here, we present a cell-based computational model visualizing cambium activity and integrating the function of central cambium regulators. Performing iterative comparisons of plant and model anatomies, we conclude that the receptor-like kinase PXY and its ligand CLE41 are part of a minimal framework sufficient for instructing tissue organization. By integrating tissue-specific cell wall stiffness values, we moreover probe the influence of physical constraints on tissue geometry. Our model highlights the role of intercellular communication within the cambium and shows that a limited number of factors are sufficient to create radial growth by bidirectional tissue production. |
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| Item Description: | Gesehen am 21.06.2023 |
| Physical Description: | Online Resource |
| ISSN: | 2050-084X |
| DOI: | 10.7554/eLife.66627 |