Management, vaccination status and COVID-19 morbidity of patients with Gaucher disease in Germany during the COVID-19 pandemic = Behandlung, Impfstatus und COVID-19-Morbidität von Patienten mit Morbus Gaucher in Deutschland während der SARS-CoV2-Pandemie
Background: Continuation of standard management of Gaucher disease (GD) has been challenging during the COVID-19 pandemic, resulting in infrequent/missed infusions and follow-up appointments. Little data are available on the consequences of these changes and on the SARS-CoV-2 vaccinations in German...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10.01.2023
|
| In: |
Zeitschrift für Gastroenterologie
Year: 2023, Jahrgang: 61, Heft: 04, Pages: 375-380 |
| ISSN: | 1439-7803 |
| DOI: | 10.1055/a-1821-9009 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1055/a-1821-9009 Verlag, lizenzpflichtig, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/a-1821-9009 
|
| Verfasserangaben: | Claus Niederau, Claudia Regenbogen, Hans-Martin Fruehauf, Martin Merkel, Athanasia Ziagaki, Eugen Mengel, Christoph Baerwald, Nicole Muschol, Christian Staufner, Christina Lampe, Anton Gillessen, Jan Philipp Koehler, Stephan vom Dahl |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1850912688 | ||
| 003 | DE-627 | ||
| 005 | 20250113004027.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230623s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1055/a-1821-9009 |2 doi | |
| 035 | |a (DE-627)1850912688 | ||
| 035 | |a (DE-599)KXP1850912688 | ||
| 035 | |a (OCoLC)1389528039 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Niederau, Claus |e VerfasserIn |0 (DE-588)120899175 |0 (DE-627)080956084 |0 (DE-576)292437242 |4 aut | |
| 245 | 1 | 0 | |a Management, vaccination status and COVID-19 morbidity of patients with Gaucher disease in Germany during the COVID-19 pandemic |b = Behandlung, Impfstatus und COVID-19-Morbidität von Patienten mit Morbus Gaucher in Deutschland während der SARS-CoV2-Pandemie |c Claus Niederau, Claudia Regenbogen, Hans-Martin Fruehauf, Martin Merkel, Athanasia Ziagaki, Eugen Mengel, Christoph Baerwald, Nicole Muschol, Christian Staufner, Christina Lampe, Anton Gillessen, Jan Philipp Koehler, Stephan vom Dahl |
| 246 | 3 | 1 | |a Behandlung, Impfstatus und COVID-19-Morbidität von Patienten mit Morbus Gaucher in Deutschland während der SARS-CoV2-Pandemie |
| 264 | 1 | |c 10.01.2023 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 23.06.2023 | ||
| 520 | |a Background: Continuation of standard management of Gaucher disease (GD) has been challenging during the COVID-19 pandemic, resulting in infrequent/missed infusions and follow-up appointments. Little data are available on the consequences of these changes and on the SARS-CoV-2 vaccinations in German GD patients. Methods: A survey with 22 questions about GD management during the pandemic was sent to 19 German Gaucher centres. It was answered by 11/19 centres caring for 257 GD patients (almost ¾ of the German GD population); 245 patients had type 1 and 12 had type 3 GD; 240 were ≥ 18 years old. Results: Monitoring intervals were prolonged in 8/11 centres from a median of 9 to 12 months. Enzyme replacement therapy (ERT) was changed to home ERT in 4 patients and substituted by oral substrate reduction therapy (SRT) in 6 patients. From March 2020 to October 2021, no serious complications of GD were documented. Only 4 SARS-CoV-2 infections were reported (1.6%). Two infections were asymptomatic and two mild; all occurred in adult type 1, non-splenectomized patients on ERT. Vaccination rate in adult GD was 79.5% (95.3% mRNA vaccines). Serious vaccination complications were not reported. Conclusions: The COVID-19 pandemic has lowered the threshold for switching from practice- or hospital-based ERT to home therapy or to SRT. No major GD complication was documented during the pandemic. Infection rate with SARS-CoV-2 in GD may rather be lower than expected, and its severity is mild. Vaccination rates are high in GD patients and vaccination was well tolerated. | ||
| 700 | 1 | |a Regenbogen, Claudia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fruehauf, Hans-Martin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Merkel, Martin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ziagaki, Athanasia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mengel, Eugen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Baerwald, Christoph |e VerfasserIn |4 aut | |
| 700 | 1 | |a Muschol, Nicole |e VerfasserIn |4 aut | |
| 700 | 1 | |a Staufner, Christian |d 1980- |e VerfasserIn |0 (DE-588)141097515 |0 (DE-627)703880950 |0 (DE-576)321299469 |4 aut | |
| 700 | 1 | |a Lampe, Christina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gillessen, Anton |e VerfasserIn |4 aut | |
| 700 | 1 | |a Koehler, Jan Philipp |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Vom Dahl, Stephan |d 1962- |e VerfasserIn |0 (DE-588)120356171 |0 (DE-627)080623484 |0 (DE-576)169797325 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Zeitschrift für Gastroenterologie |d Stuttgart [u.a.] : Thieme, 1997 |g 61(2023), 04 vom: Jan., Seite 375-380 |h Online-Ressource |w (DE-627)326647368 |w (DE-600)2041790-1 |w (DE-576)256442215 |x 1439-7803 |7 nnas |a Management, vaccination status and COVID-19 morbidity of patients with Gaucher disease in Germany during the COVID-19 pandemic = Behandlung, Impfstatus und COVID-19-Morbidität von Patienten mit Morbus Gaucher in Deutschland während der SARS-CoV2-Pandemie |
| 773 | 1 | 8 | |g volume:61 |g year:2023 |g number:04 |g month:01 |g pages:375-380 |g extent:6 |a Management, vaccination status and COVID-19 morbidity of patients with Gaucher disease in Germany during the COVID-19 pandemic = Behandlung, Impfstatus und COVID-19-Morbidität von Patienten mit Morbus Gaucher in Deutschland während der SARS-CoV2-Pandemie |
| 856 | 4 | 0 | |u https://doi.org/10.1055/a-1821-9009 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.thieme-connect.de/DOI/DOI?10.1055/a-1821-9009 |x Verlag |z lizenzpflichtig |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20230623 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 141097515 |a Staufner, Christian |m 141097515:Staufner, Christian |d 910000 |d 910500 |d 50000 |e 910000PS141097515 |e 910500PS141097515 |e 50000PS141097515 |k 0/910000/ |k 1/910000/910500/ |k 0/50000/ |p 9 | ||
| 999 | |a KXP-PPN1850912688 |e 4342749785 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1850912688","language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 23.06.2023"],"titleTranslated":[{"translated":"Behandlung, Impfstatus und COVID-19-Morbidität von Patienten mit Morbus Gaucher in Deutschland während der SARS-CoV2-Pandemie"}],"person":[{"family":"Niederau","given":"Claus","display":"Niederau, Claus","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Claudia","family":"Regenbogen","role":"aut","display":"Regenbogen, Claudia","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Fruehauf, Hans-Martin","roleDisplay":"VerfasserIn","given":"Hans-Martin","family":"Fruehauf"},{"family":"Merkel","given":"Martin","roleDisplay":"VerfasserIn","display":"Merkel, Martin","role":"aut"},{"display":"Ziagaki, Athanasia","roleDisplay":"VerfasserIn","role":"aut","family":"Ziagaki","given":"Athanasia"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Mengel, Eugen","given":"Eugen","family":"Mengel"},{"given":"Christoph","family":"Baerwald","role":"aut","roleDisplay":"VerfasserIn","display":"Baerwald, Christoph"},{"display":"Muschol, Nicole","roleDisplay":"VerfasserIn","role":"aut","family":"Muschol","given":"Nicole"},{"display":"Staufner, Christian","roleDisplay":"VerfasserIn","role":"aut","family":"Staufner","given":"Christian"},{"given":"Christina","family":"Lampe","role":"aut","display":"Lampe, Christina","roleDisplay":"VerfasserIn"},{"given":"Anton","family":"Gillessen","role":"aut","display":"Gillessen, Anton","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Koehler, Jan Philipp","roleDisplay":"VerfasserIn","given":"Jan Philipp","family":"Koehler"},{"roleDisplay":"VerfasserIn","display":"Vom Dahl, Stephan","role":"aut","family":"Vom Dahl","given":"Stephan"}],"title":[{"title":"Management, vaccination status and COVID-19 morbidity of patients with Gaucher disease in Germany during the COVID-19 pandemic","subtitle":" = Behandlung, Impfstatus und COVID-19-Morbidität von Patienten mit Morbus Gaucher in Deutschland während der SARS-CoV2-Pandemie","title_sort":"Management, vaccination status and COVID-19 morbidity of patients with Gaucher disease in Germany during the COVID-19 pandemic"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1439-7803"],"eki":["326647368"],"doi":["10.1055/s-00000094"],"zdb":["2041790-1"]},"origin":[{"dateIssuedDisp":"1997-","dateIssuedKey":"1997","publisher":"Thieme","publisherPlace":"Stuttgart [u.a.]"}],"recId":"326647368","language":["ger"],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 07.11.2013"],"disp":"Management, vaccination status and COVID-19 morbidity of patients with Gaucher disease in Germany during the COVID-19 pandemic = Behandlung, Impfstatus und COVID-19-Morbidität von Patienten mit Morbus Gaucher in Deutschland während der SARS-CoV2-PandemieZeitschrift für Gastroenterologie","part":{"year":"2023","issue":"04","pages":"375-380","text":"61(2023), 04 vom: Jan., Seite 375-380","volume":"61","extent":"6"},"pubHistory":["Nachgewiesen 38.2000 -"],"titleTranslated":[{"translated":"German journal of gastroenterology"}],"title":[{"subtitle":"offizielles Organ: Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten mit Sektion Gastroenterologische Endoskopie ; Österreichische Gesellschaft für Gastroenterologie und Hepatologie ; Ungarische Gesellschaft für Gastroenterologie und Hepatologie = German journal of gastroenterology","title":"Zeitschrift für Gastroenterologie","title_sort":"Zeitschrift für Gastroenterologie"}]}],"physDesc":[{"extent":"6 S."}],"name":{"displayForm":["Claus Niederau, Claudia Regenbogen, Hans-Martin Fruehauf, Martin Merkel, Athanasia Ziagaki, Eugen Mengel, Christoph Baerwald, Nicole Muschol, Christian Staufner, Christina Lampe, Anton Gillessen, Jan Philipp Koehler, Stephan vom Dahl"]},"id":{"eki":["1850912688"],"doi":["10.1055/a-1821-9009"]},"origin":[{"dateIssuedDisp":"10.01.2023","dateIssuedKey":"2023"}]} | ||
| SRT | |a NIEDERAUCLMANAGEMENT1001 | ||