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Ventilation-perfusion ratio in perflubron during partial liquid ventilation

Functional magnetic resonance imaging (fMRI) of fluorine-19 allows for the mapping of oxygen partial pressure within perfluorocarbons in the alveolar space (PAO2). Theoretically, fMRI-detected PAO2 can be combined with the Fick principle approach, i.e., a mass balance of oxygen uptake by ventilation...

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Bibliographic Details
Main Authors: Scholz, Alexander-Wigbert (Author) , Eberle, Balthasar (Author) , Heußel, Claus Peter (Author) , David, Matthias (Author) , Schmittner, Marc (Author) , Quintel, Michael (Author) , Schreiber, Laura M. (Author) , Weiler, Norbert (Author)
Format: Article (Journal)
Language:English
Published: May 6, 2010
In: Anesthesia & analgesia
Year: 2010, Volume: 110, Issue: 6, Pages: 1661-1668
ISSN:1526-7598
DOI:10.1213/ANE.0b013e3181d3e1d5
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1213/ANE.0b013e3181d3e1d5
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/anesthesia-analgesia/Fulltext/2010/06000/Ventilation_Perfusion_Ratio_in_Perflubron_During.24.aspx
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Author Notes:Alexander-Wigbert K. Scholz, Balthasar Eberle, Claus P. Heussel, Matthias David, Marc D. Schmittner, Michael Quintel, Laura M. Schreiber, and Norbert Weiler
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Summary:Functional magnetic resonance imaging (fMRI) of fluorine-19 allows for the mapping of oxygen partial pressure within perfluorocarbons in the alveolar space (PAO2). Theoretically, fMRI-detected PAO2 can be combined with the Fick principle approach, i.e., a mass balance of oxygen uptake by ventilation and delivery by perfusion, to quantify the ventilation-perfusion ratio (VA/Q) of a lung region: The mixed venous blood and the inspiratory oxygen fraction, which are equal for all lung regions, are measured. In addition, the local expiratory oxygen fraction and the end capillary oxygen content, both of which may differ between the lung regions, are calculated using the fMRI-detected PAO2. We investigated this approach by numerical simulations and applied it to quantify local VA/Q in the perfluorocarbons during partial liquid ventilation.
Item Description:Gesehen am 27.06.2023
Physical Description:Online Resource
ISSN:1526-7598
DOI:10.1213/ANE.0b013e3181d3e1d5

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