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Sinonasal malignancies: histopathological entities, regional involvement and long-term outcome

Background: To assess a large patient cohort with sinonasal malignancies focusing on regional involvement, recurrence and oncological outcome. Methods: Patients (n = 144) with malignant tumors of the nasal cavity and paranasal sinuses were treated at our tertiary referral center between 2008 and 201...

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Main Authors: Anschuetz, Lukas (Author) , Hohenberger, Ralph (Author) , Käcker, Christoph (Author) , Elicin, Olgun (Author) , Giger, Roland (Author) , Caversaccio, Marco (Author)
Format: Article (Journal)
Language:English
Published: 28 April 2023
In: Journal of otolaryngology, head & neck surgery
Year: 2023, Volume: 52, Pages: 1-9
ISSN:1916-0216
DOI:10.1186/s40463-023-00627-8
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s40463-023-00627-8
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Author Notes:Lukas Anschuetz, Ralph Hohenberger, Christoph Kaecker, Olgun Elicin, Roland Giger and Marco Caversaccio
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Summary:Background: To assess a large patient cohort with sinonasal malignancies focusing on regional involvement, recurrence and oncological outcome. Methods: Patients (n = 144) with malignant tumors of the nasal cavity and paranasal sinuses were treated at our tertiary referral center between 2008 and 2019. A chart review on patient and tumor characteristics, treatment and long-term outcome was performed. Results: Most frequent histological types were squamous cell carcinoma (SCC) (n = 74), adenocarcinoma (n = 24) and mucosal melanoma (n = 18). Primary therapy was surgery in 66% of patients (n = 95) of which 65.8% (n = 66) received adjuvant radiotherapy. Twenty patients (13.8%) were initially staged as cN + and in seven cases, pN + status was histopathologically confirmed. Fifty-six of 130 patients (43.1%) had a relapse after curative intended therapy, including nine loco-regional (6.9%) and seven isolated regional recurrences (5.4%). Twelve of these 16 patients with (loco-)regional recurrence had SCC. Adenoid cystic carcinoma (87.5%) and SCC (65.3%) showed the best long-term overall survival. Conclusions: Regional involvement and regional recurrence are scarce. Because of rarity and heterogeneity, evidence on therapeutic management is sparse resulting in the lack of clinical guidelines.
Item Description:Gesehen am 28.06.2023
Physical Description:Online Resource
ISSN:1916-0216
DOI:10.1186/s40463-023-00627-8

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