Sinonasal malignancies: histopathological entities, regional involvement and long-term outcome
Background: To assess a large patient cohort with sinonasal malignancies focusing on regional involvement, recurrence and oncological outcome. Methods: Patients (n = 144) with malignant tumors of the nasal cavity and paranasal sinuses were treated at our tertiary referral center between 2008 and 201...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
28 April 2023
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| In: |
Journal of otolaryngology, head & neck surgery
Year: 2023, Volume: 52, Pages: 1-9 |
| ISSN: | 1916-0216 |
| DOI: | 10.1186/s40463-023-00627-8 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s40463-023-00627-8
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| Author Notes: | Lukas Anschuetz, Ralph Hohenberger, Christoph Kaecker, Olgun Elicin, Roland Giger and Marco Caversaccio |
MARC
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| 245 | 1 | 0 | |a Sinonasal malignancies |b histopathological entities, regional involvement and long-term outcome |c Lukas Anschuetz, Ralph Hohenberger, Christoph Kaecker, Olgun Elicin, Roland Giger and Marco Caversaccio |
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| 520 | |a Background: To assess a large patient cohort with sinonasal malignancies focusing on regional involvement, recurrence and oncological outcome. Methods: Patients (n = 144) with malignant tumors of the nasal cavity and paranasal sinuses were treated at our tertiary referral center between 2008 and 2019. A chart review on patient and tumor characteristics, treatment and long-term outcome was performed. Results: Most frequent histological types were squamous cell carcinoma (SCC) (n = 74), adenocarcinoma (n = 24) and mucosal melanoma (n = 18). Primary therapy was surgery in 66% of patients (n = 95) of which 65.8% (n = 66) received adjuvant radiotherapy. Twenty patients (13.8%) were initially staged as cN + and in seven cases, pN + status was histopathologically confirmed. Fifty-six of 130 patients (43.1%) had a relapse after curative intended therapy, including nine loco-regional (6.9%) and seven isolated regional recurrences (5.4%). Twelve of these 16 patients with (loco-)regional recurrence had SCC. Adenoid cystic carcinoma (87.5%) and SCC (65.3%) showed the best long-term overall survival. Conclusions: Regional involvement and regional recurrence are scarce. Because of rarity and heterogeneity, evidence on therapeutic management is sparse resulting in the lack of clinical guidelines. | ||
| 650 | 4 | |a Mucosal melanoma | |
| 650 | 4 | |a Nasal cancer | |
| 650 | 4 | |a Rare cancer | |
| 650 | 4 | |a Regional recurrence | |
| 650 | 4 | |a Squamous cell carcinoma | |
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| 700 | 1 | |a Elicin, Olgun |e VerfasserIn |4 aut | |
| 700 | 1 | |a Giger, Roland |e VerfasserIn |4 aut | |
| 700 | 1 | |a Caversaccio, Marco |e VerfasserIn |4 aut | |
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