Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes
SPP (signal peptide peptidase) is an aspartyl intramembrane cleaving protease, which processes a subset of signal peptides, and is linked to the quality control of ER (endoplasmic reticulum) membrane proteins. We analysed SPP interactions with signal peptides and other membrane proteins by co-immuno...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
3 March 2010
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| In: |
Biochemical journal
Year: 2010, Volume: 427, Issue: 3, Pages: 523-534 |
| ISSN: | 1470-8728 |
| DOI: | 10.1042/BJ20091005 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1042/BJ20091005 Verlag, lizenzpflichtig, Volltext: https://portlandpress.com/biochemj/article/427/3/523/45424/Signal-peptide-peptidase-SPP-assembles-with Verlag, lizenzpflichtig, Volltext: https://portlandpress.com/biochemj/article-pdf/427/3/523/662748/bj4270523.pdf 
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| Author Notes: | Bianca Schrul, Katja Kapp, Irmgard Sinning and Bernhard Dobberstein |
| Summary: | SPP (signal peptide peptidase) is an aspartyl intramembrane cleaving protease, which processes a subset of signal peptides, and is linked to the quality control of ER (endoplasmic reticulum) membrane proteins. We analysed SPP interactions with signal peptides and other membrane proteins by co-immunoprecipitation assays. We found that SPP interacts specifically and tightly with a large range of newly synthesized membrane proteins, including signal peptides, preproteins and misfolded membrane proteins, but not with all co-expressed type II membrane proteins... |
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| Item Description: | Das PDF ist nur von der Artikelliste des Heftes aus aufrufbar Gesehen am 04.07.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1470-8728 |
| DOI: | 10.1042/BJ20091005 |