Accurate prediction of neuroblastoma outcome based on miRNA expression profiles

For neuroblastoma, the most common extracranial tumour of childhood, identification of new biomarkers and potential therapeutic targets is mandatory to improve risk stratification and survival rates. MicroRNAs are deregulated in most cancers, including neuroblastoma. In this study, we analysed 430 m...

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Main Authors: Schulte, Johannes Hubertus (Author) , Schowe, Benjamin (Author) , Mestdagh, Pieter (Author) , Kaderali, Lars (Author) , Kalaghatgi, Prabhav (Author) , Schlierf, Stefanie (Author) , Vermeulen, Joelle (Author) , Brockmeyer, Bent (Author) , Pajtler, Kristian (Author) , Thor, Theresa (Author) , de Preter, Katleen (Author) , Speleman, Frank (Author) , Morik, Katharina (Author) , Eggert, Angelika (Author) , Vandesompele, Jo (Author) , Schramm, Alexander (Author)
Format: Article (Journal)
Language:English
Published: 5 May 2010
In: International journal of cancer
Year: 2010, Volume: 127, Issue: 10, Pages: 2374-2385
ISSN:1097-0215
DOI:10.1002/ijc.25436
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1002/ijc.25436
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.25436
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Author Notes:Johannes H. Schulte, Benjamin Schowe, Pieter Mestdagh, Lars Kaderali, Prabhav Kalaghatgi, Stefanie Schlierf, Joelle Vermeulen, Bent Brockmeyer, Kristian Pajtler, Theresa Thor, Katleen de Preter, Frank Speleman, Katharina Morik, Angelika Eggert, Jo Vandesompele and Alexander Schramm
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Summary:For neuroblastoma, the most common extracranial tumour of childhood, identification of new biomarkers and potential therapeutic targets is mandatory to improve risk stratification and survival rates. MicroRNAs are deregulated in most cancers, including neuroblastoma. In this study, we analysed 430 miRNAs in 69 neuroblastomas by stem-loop RT-qPCR. Prediction of event-free survival (EFS) with support vector machines (SVM) and actual survival times with Cox regression-based models (CASPAR) were highly accurate and were independently validated...
Item Description:Gesehen am 05.07.2023
Physical Description:Online Resource
ISSN:1097-0215
DOI:10.1002/ijc.25436