Helical tomotherapy of lymph node-negative early-stage breast cancer after breast-conserving surgery: long-term results
Background/Aim: Adjuvant radiotherapy is an integral part of the interdisciplinary curative treatment of breast cancer. We aimed to examine the long-term clinical results of helical tomotherapy in female patients with local restricted, lymph node negative breast cancer after breast-conserving surger...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
April 25, 2023
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| In: |
Anticancer research
Year: 2023, Volume: 43, Issue: 5, Pages: 2041-2053 |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.16365 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.21873/anticanres.16365 Verlag, lizenzpflichtig, Volltext: https://ar.iiarjournals.org/content/43/5/2041 
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| Author Notes: | Felix Zwicker, Rudolf Klepper, Henrik Hauswald, Sebastian Hoefel, Luis Raether, Peter E. Huber, Juergen Debus, Michael Schempp |
| Summary: | Background/Aim: Adjuvant radiotherapy is an integral part of the interdisciplinary curative treatment of breast cancer. We aimed to examine the long-term clinical results of helical tomotherapy in female patients with local restricted, lymph node negative breast cancer after breast-conserving surgery. Patients and Methods: In this single-centre analysis, 219 female patients with early-stage breast cancer (T1/2) and no lymph node metastasis (N0) following breast-conserving surgery and sentinel-node biopsy were treated with adjuvant fractionated whole breast radiation therapy using helical tomotherapy. When boost irradiation was indicated, it was administered sequentially or using the simultaneous-integrated boost technique. Local control (LC), metastasis and survival rates, acute toxicity, late toxicity, and secondary malignancy rates were analysed retrospectively. Results: The mean follow-up time was 71 months. The 5- and 8-year overall survival (OS) rates were 97.7% and 92.1%, respectively. The 5- and 8-year LC rates were 99.5% and 98.2%, while the 5- and 8-year metastasis-free survival (MFS) rates of 97.4% and 94.3%, respectively. Patients with G3 grading or negative hormone receptor status did not show significantly different results. Acute erythema occurred in 79% (grade 0-2) and 21% (grade 3) of the patients. Lymphedema of the ipsilateral arm and pneumonitis occurred in 6.4% and 1.8% of the treated patients. None of the patients developed >grade 3 toxicities during follow-up, while 1.8% developed a secondary malignancy during follow-up. Conclusion: Helical tomotherapy showed excellent long-term results and low toxicity rates. The incidence rates of secondary malignancy were relatively low and correlated with pre-existing data on radiotherapy, suggesting wider implementation of helical tomotherapy in adjuvant radiotherapy for breast cancer patients. |
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| Item Description: | Gesehen am 05.07.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.16365 |