An unbiased genome-wide analysis of zinc-finger nuclease specificity

Zinc-finger nucleases allow targeted genetic modification at loci chosen by the investigator, but the extent of their off-target activity—which could be toxic to cells—has not been evaluated experimentally on a genome-wide scale. Gabriel et al. document the off- and on-target activity of zinc-finger...

Descripción completa

Detalles Bibliográficos

Autores principales:	Gabriel, Richard (Autor) , Lombardo, Angelo (Autor) , Arens, Anne (Autor) , Miller, Jeffrey C. (Autor) , Genovese, Pietro (Autor) , Käppel, Christine (Autor) , Nowrouzi, Ali (Autor) , Bartholomä, Cynthia C. (Autor) , Wang, Jianbin (Autor) , Friedman, Geoffrey (Autor) , Holmes, Michael C. (Autor) , Gregory, Philip D. (Autor) , Glimm, Hanno (Autor) , Schmidt, Manfred (Autor) , Naldini, Luigi (Autor) , Kalle, Christof von (Autor)
Formato:	Article (Journal)
Lenguaje:	inglés
Publicado:	7 August 2011
In:	Nature biotechnology Year: 2011, Volumen: 29, Número: 9, Pages: 816-823
ISSN:	1546-1696
DOI:	10.1038/nbt.1948
Acceso en línea:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nbt.1948 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nbt.1948
Notas de Autor:	Richard Gabriel, Angelo Lombardo, Anne Arens, Jeffrey C. Miller, Pietro Genovese, Christine Kaeppel, Ali Nowrouzi, Cynthia C. Bartholomae, Jianbin Wang, Geoffrey Friedman, Michael C. Holmes, Philip D. Gregory, Hanno Glimm, Manfred Schmidt, Luigi Naldini & Christof von Kalle