Consequences of trisomy syndromes: 21 and beyond
The mechanisms underlying pathologies in Down syndrome remain poorly understood. In this forum article we compare the cellular phenotypes of chromosome 21 trisomy with other trisomic cells. We argue that both effects of the extra chromosome 21 and the global consequences of chromosome gain must be c...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
21 February 2023
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| In: |
Trends in genetics
Year: 2023, Volume: 39, Issue: 3, Pages: 172-174 |
| ISSN: | 1362-4555 |
| DOI: | 10.1016/j.tig.2022.11.004 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tig.2022.11.004 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0168952522002918 
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| Author Notes: | Maria Krivega and Zuzana Storchova |
| Summary: | The mechanisms underlying pathologies in Down syndrome remain poorly understood. In this forum article we compare the cellular phenotypes of chromosome 21 trisomy with other trisomic cells. We argue that both effects of the extra chromosome 21 and the global consequences of chromosome gain must be considered to understand complex pathologies of Down syndrome. |
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| Item Description: | Online verfügbar 7 December 2022, Version des Artikels 21 February 2023 Gesehen am 10.07.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1362-4555 |
| DOI: | 10.1016/j.tig.2022.11.004 |