A randomized study of endobronchial valves for advanced emphysema
Endobronchial valves that allow air to escape from a pulmonary lobe but not enter it can induce a reduction in lobar volume that may thereby improve lung function and exercise tolerance in patients with pulmonary hyperinflation related to advanced emphysema. We compared the safety and efficacy of en...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 23, 2010
|
| In: |
The New England journal of medicine
Year: 2010, Volume: 363, Issue: 13, Pages: 1233-1244 |
| ISSN: | 1533-4406 |
| DOI: | 10.1056/NEJMoa0900928 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1056/NEJMoa0900928 Verlag, lizenzpflichtig, Volltext: https://www.nejm.org/doi/full/10.1056/NEJMoa0900928 
|
| Author Notes: | Frank C. Sciurba, Armin Ernst, Felix J.F. Herth, Charlie Strange, Gerard J. Criner, Charles H. Marquette, Kevin L. Kovitz, Richard P. Chiacchierini, Jonathan Goldin, and Geoffrey McLennan for the VENT Study Research Group |
| Summary: | Endobronchial valves that allow air to escape from a pulmonary lobe but not enter it can induce a reduction in lobar volume that may thereby improve lung function and exercise tolerance in patients with pulmonary hyperinflation related to advanced emphysema. We compared the safety and efficacy of endobronchial-valve therapy in patients with heterogeneous emphysema versus standard medical care. Efficacy end points were percent changes in the forced expiratory volume in 1 second (FEV1) and the 6-minute walk test on intention-to-treat analysis. We assessed safety on the basis of the rate of a composite of six major complications. |
|---|---|
| Item Description: | Gesehen am 12.07.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1533-4406 |
| DOI: | 10.1056/NEJMoa0900928 |