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Synthetic antitumor vaccines containing MUC1 glycopeptides with two immunodominant domains: induction of a strong immune response against breast tumor tissues

A shot in the arm for cancer treatment: Two MUC1 tetanus toxoid vaccines were synthesized and induced a strong immune response in mice. The antibodies elicited by the vaccines show a high selectivity for the tumor cells in mammary carcinoma tissues and also distinguish between tumor tissues at diffe...

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Bibliographic Details
Main Authors: Gaidzik, Nikola (Author) , Kaiser, Anton (Author) , Kowalczyk, Danuta (Author) , Westerlind, Ulrika (Author) , Gerlitzki, Bastian (Author) , Sinn, Peter (Author) , Schmitt, Edgar (Author) , Kunz, Horst (Author)
Format: Article (Journal)
Language:English
Published: September 9, 2011
In: Angewandte Chemie. International edition
Year: 2011, Volume: 50, Issue: 42, Pages: 9977-9981
ISSN:1521-3773
DOI:10.1002/anie.201104529
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/anie.201104529
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201104529
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Author Notes:Nikola Gaidzik, Anton Kaiser, Danuta Kowalczyk, Ulrika Westerlind, Bastian Gerlitzki, Hans Peter Sinn, Edgar Schmitt, and Horst Kunz
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Summary:A shot in the arm for cancer treatment: Two MUC1 tetanus toxoid vaccines were synthesized and induced a strong immune response in mice. The antibodies elicited by the vaccines show a high selectivity for the tumor cells in mammary carcinoma tissues and also distinguish between tumor tissues at different stages.
Item Description:Gesehen am 12.07.2023
Physical Description:Online Resource
ISSN:1521-3773
DOI:10.1002/anie.201104529

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