Direct and indirect vaccination effects on SARS-CoV-2 infection in day-care centres: evaluating the policy for early vaccination of day-care staff in Germany, 2021
To mitigate the known high transmission risk in day-care facilities for children aged 0-6 years, day-care staff were given priority for SARS-CoV-2 vaccination in Rhineland-Palatinate, Germany, in March 2021. This study assessed direct and indirect effects of early vaccination of day-care staff on SA...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
04 May 2023
|
| In: |
Epidemiology and infection
Year: 2023, Volume: 151, Pages: 1-4 |
| ISSN: | 1469-4409 |
| DOI: | 10.1017/S0950268823000638 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1017/S0950268823000638 Verlag, kostenfrei, Volltext: https://www.cambridge.org/core/journals/epidemiology-and-infection/article/direct-and-indirect-vaccination-effects-on-sarscov2-infection-in-daycare-centres-evaluating-the-policy-for-early-vaccination-of-daycare-staff-in-germany-2021/72B4D2BEC7354CEBDA4697950D66F350 
|
| Author Notes: | Anja Schoeps, Jan Walter, Manfred Vogt, Stefan Bent, Philipp Zanger and the Palatina Public Health Study Group |
| Summary: | To mitigate the known high transmission risk in day-care facilities for children aged 0-6 years, day-care staff were given priority for SARS-CoV-2 vaccination in Rhineland-Palatinate, Germany, in March 2021. This study assessed direct and indirect effects of early vaccination of day-care staff on SARS-CoV-2 transmission in daycares with the aim to provide a basis for the prioritisation of scarce vaccines in the future. Data came from statutory infectious disease notifications in educational institutions and from in-depth investigations by the district public health authorities. Using interrupted time series analyses, we measured the effect of mRNA-based vaccination of day-care staff on SARS-CoV-2 infections and transmission. Among 566 index cases from day-care centres, the mean number of secondary SARS-CoV-2 infections per index case dropped by −0.60 case per month after March 2021. The proportion of staff among all cases reported from daycares was around 60% in the pre-interruption phase and significantly decreased by 27 percentage points immediately in March 2021 and by further 6 percentage points each month in the post-interruption phase. Early vaccination of day-care staff reduced SARS-CoV-2 cases in the overall day-care setting and thus also protected unvaccinated children. This should inform future decisions on vaccination prioritisation. |
|---|---|
| Item Description: | Gesehen am 12.07.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1469-4409 |
| DOI: | 10.1017/S0950268823000638 |