Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo

The intercalated disc (ID) is a highly specialized cell-cell contact structure that ensures mechanical and electric coupling of contracting cardiomyocytes. Recently, the ID has been recognized to be a hot spot of cardiac disease, in particular inherited cardiomyopathy. Given its complex structure an...

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Main Authors: Seeger, Thalia Sandra (Author) , Frank, Derk (Author) , Rohr, Claudia (Author) , Will, Rainer D. (Author) , Just, Steffen (Author) , Grund, Christine (Author) , Lyon, Robert (Author) , Luedde, Mark (Author) , Koegl, Manfred (Author) , Sheikh, Farah (Author) , Rottbauer, Wolfgang (Author) , Franke, Werner W. (Author) , Katus, Hugo (Author) , Olson, Eric N. (Author) , Frey, Norbert (Author)
Format: Article (Journal)
Language:English
Published: 21 Jan 2010
In: Circulation research
Year: 2010, Volume: 106, Issue: 5, Pages: 880-890
ISSN:1524-4571
DOI:10.1161/CIRCRESAHA.109.213256
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1161/CIRCRESAHA.109.213256
Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.109.213256
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Author Notes:Thalia S. Seeger, Derk Frank, Claudia Rohr, Rainer Will, Steffen Just, Christine Grund, Robert Lyon, Mark Luedde, Manfred Koegl, Farah Sheikh, Wolfgang Rottbauer, Werner W. Franke, Hugo A. Katus, Eric N. Olson, Norbert Frey
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Summary:The intercalated disc (ID) is a highly specialized cell-cell contact structure that ensures mechanical and electric coupling of contracting cardiomyocytes. Recently, the ID has been recognized to be a hot spot of cardiac disease, in particular inherited cardiomyopathy. Given its complex structure and function we hypothesized that important molecular constituents of the ID still remain unknown.
Item Description:Gesehen am 12.07.2023
Physical Description:Online Resource
ISSN:1524-4571
DOI:10.1161/CIRCRESAHA.109.213256