Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo
The intercalated disc (ID) is a highly specialized cell-cell contact structure that ensures mechanical and electric coupling of contracting cardiomyocytes. Recently, the ID has been recognized to be a hot spot of cardiac disease, in particular inherited cardiomyopathy. Given its complex structure an...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
21 Jan 2010
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| In: |
Circulation research
Year: 2010, Volume: 106, Issue: 5, Pages: 880-890 |
| ISSN: | 1524-4571 |
| DOI: | 10.1161/CIRCRESAHA.109.213256 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1161/CIRCRESAHA.109.213256 Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.109.213256 |
| Author Notes: | Thalia S. Seeger, Derk Frank, Claudia Rohr, Rainer Will, Steffen Just, Christine Grund, Robert Lyon, Mark Luedde, Manfred Koegl, Farah Sheikh, Wolfgang Rottbauer, Werner W. Franke, Hugo A. Katus, Eric N. Olson, Norbert Frey |
| Summary: | The intercalated disc (ID) is a highly specialized cell-cell contact structure that ensures mechanical and electric coupling of contracting cardiomyocytes. Recently, the ID has been recognized to be a hot spot of cardiac disease, in particular inherited cardiomyopathy. Given its complex structure and function we hypothesized that important molecular constituents of the ID still remain unknown. |
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| Item Description: | Gesehen am 12.07.2023 |
| Physical Description: | Online Resource |
| ISSN: | 1524-4571 |
| DOI: | 10.1161/CIRCRESAHA.109.213256 |