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Associations of SLC6A4 methylation with salivary cortisol, salivary alpha-amylase, and subjective stress in everyday life

Dysregulations of the hypothalamic-pituitary-adrenal (HPA) and sympatho-adrenal medullary (SAM) axis are associated with mental and somatic illness. However, there is lack of knowledge regarding the molecular mechanisms underlying these effects. Epigenetic states in the serotonin transporter gene (S...

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Main Authors: Stoffel, Martin (Author) , Rahn, Stefanie (Author) , Neubauer, Andreas B. (Author) , Moessner, Markus (Author) , Aguilar-Raab, Corina (Author) , Ditzen, Beate (Author)
Format: Article (Journal)
Language:English
Published: July 2023
In: Psychoneuroendocrinology
Year: 2023, Volume: 153, Pages: 1-9
ISSN:1873-3360
DOI:10.1016/j.psyneuen.2023.106283
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.psyneuen.2023.106283
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0306453023002615
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Author Notes:Martin Stoffel, Stefanie Rahn, Andreas B. Neubauer, Markus Moessner, Corina Aguilar-Raab, Beate Ditzen
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Summary:Dysregulations of the hypothalamic-pituitary-adrenal (HPA) and sympatho-adrenal medullary (SAM) axis are associated with mental and somatic illness. However, there is lack of knowledge regarding the molecular mechanisms underlying these effects. Epigenetic states in the serotonin transporter gene (SLC6A4) were shown to be associated with stress in various forms. We hypothesized that levels of DNA methylation (DNAm) of SLC6A4 would be associated with altered SAM- and HPA regulation in daily life. N = 74 healthy persons participated in the study. ...
Item Description:Online veröffentlicht am 28. April 2023
Gesehen am 07.12.2023
Physical Description:Online Resource
ISSN:1873-3360
DOI:10.1016/j.psyneuen.2023.106283

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