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CEST imaging of the APT and ssMT predict the overall survival of patients with glioma at the first follow-up after completion of radiotherapy at 3T

Outcome prediction of patients with glioma early after the completion of radiotherapy represents a major clinical challenge. Previously, the prognostic value of chemical exchange saturation transfer (CEST) imaging has been demonstrated in patients with newly diagnosed glioma. The objective of this s...

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Main Authors: Knebel Doeberitz, Nikolaus von (Author) , Kroh, Florian (Author) , Breitling, Johannes (Author) , König, Laila (Author) , Maksimovic, Srdjan (Author) , Grass, Svenja (Author) , Adeberg, Sebastian (Author) , Scherer, Moritz (Author) , Unterberg, Andreas (Author) , Bendszus, Martin (Author) , Wick, Wolfgang (Author) , Bachert, Peter (Author) , Debus, Jürgen (Author) , Ladd, Mark E. (Author) , Schlemmer, Heinz-Peter (Author) , Korzowski, Andreas (Author) , Görke, Steffen (Author) , Paech, Daniel (Author)
Format: Article (Journal)
Language:English
Published: July 2023
In: Radiotherapy and oncology
Year: 2023, Volume: 184, Pages: 1-8
ISSN:1879-0887
DOI:10.1016/j.radonc.2023.109694
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.radonc.2023.109694
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167814023002323
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Author Notes:Nikolaus von Knebel Doeberitz, Florian Kroh, Johannes Breitling, Laila König, Srdjan Maksimovic, Svenja Graß, Sebastian Adeberg, Moritz Scherer, Andreas Unterberg, Martin Bendszus, Wolfgang Wick, Peter Bachert, Jürgen Debus, Mark E. Ladd, Heinz-Peter Schlemmer, Andreas Korzowski, Steffen Goerke, Daniel Paech
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Summary:Outcome prediction of patients with glioma early after the completion of radiotherapy represents a major clinical challenge. Previously, the prognostic value of chemical exchange saturation transfer (CEST) imaging has been demonstrated in patients with newly diagnosed glioma. The objective of this study was to assess the potential of amide proton transfer (APT)-, relayed nuclear Overhauser effect (rNOE)- and semi-solid magnetization transfer (ssMT)-imaging according to Zhou et al. (APTwasym), Goerke et al. (MTRRexAPT, MTRRexNOE and MTRRexMT) and Mehrabian et al. (PeakAreaAPT, PeakAreaNOE and MTconst) for the prognostication of the overall survival (OS) of patients with glioma at the first follow-up after the completion of radiotherapy.
Item Description:Online veröffentlicht: 6. Mai 2023, Artikelversion vom 18. Mai 2023
Gesehen am 07.12.2023
Physical Description:Online Resource
ISSN:1879-0887
DOI:10.1016/j.radonc.2023.109694

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